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Efficacy of TAC-302 for patients with detrusor underactivity and overactive bladder: a randomized, double-blind, placebo-controlled phase 2 study
PurposeThis multicenter, randomized, double-blind, placebo-controlled phase 2 study evaluated the efficacy and safety of TAC-302, a novel drug that...
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Management of Patients with Detrusor Hyperactivity with Impaired Contractility
Purpose of ReviewDetrusor hyperactivity and impaired contractility (DHIC) is a common condition seen in elderly patients who suffered from lower...
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Lactonase activity and status of paraoxonase 1 and oxidative stress in neonates of women with gestational diabetes mellitus
BackgroundThe level and lactonase activity of paraoxonase 1 (PON1) and their association with PON1 genetic variants and oxidative stress are unclear...
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The Effects of MicroRNAs in the Development of Heart Failure
Purpose of ReviewHeart failure is a severe clinical syndrome with complex and unclarified mechanisms, and it poses a serious threat to human health....
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Post-transplant cyclophosphamide, calcineurin inhibitor, and mycophenolate mofetil compared to anti-thymocyte globulin, calcineurin inhibitor, and methotrexate combinations as graft-versus-host disease prophylaxis post allogeneic stem cell transplantation from sibling and unrelated donors in patients with acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Post-transplant cyclophosphamide plus calcineurin inhibitor (CNI)(tacrolimus or cyclosporine A) plus mycophenolate mofetil (PTCy/TAC or CSA/MMF) and...
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Differential expression of tsRNAs and miRNAs in embryo culture medium: potential impact on embryo implantation
PurposeCan small RNA derived from embryos in conditioned embryo culture medium (ECM) influence embryo implantation?
MethodsWe employed small RNA...
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Macrophage activation syndrome in juvenile dermatomyositis: a case report and a comprehensive review of the literature
BackgroundMacrophage activation syndrome (MAS) is a severe and life-threatening syndrome associated with autoimmune diseases. The coexistence of MAS...
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Impact of HLA-mismatched unrelated transplantation in patients with adult T-cell leukemia/lymphoma
This Japanese nationwide retrospective study investigated the impact of HLA-mismatched unrelated transplantation for adult T-cell leukemia-lymphoma...
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National trends and feasibility of a robotic surgical approach in the management of patients with inflammatory bowel disease
BackgroundResearch on the utilization of robotic surgical approaches in the management of inflammatory bowel disease (IBD) is limited. The aims of...
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Archetypal sustained low-efficiency daily diafiltration (SLEDD-f) for critically ill patients requiring kidney replacement therapy: towards an adequate therapy
Sustained low-efficiency dialysis is a hybrid form of kidney replacement therapy that has gained increasing popularity as an alternative to...
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Differences in epidemiology of enteropathogens in children pre- and post-rotavirus vaccine introduction in Kilifi, coastal Kenya
BackgroundKenya introduced Rotarix ® (GlaxoSmithKline Biologicals, Rixensart, Belgium) vaccination into its national immunization programme beginning...
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Incidence of severe breakthrough SARS-CoV-2 infections in vaccinated kidney transplant and haemodialysis patients
IntroductionGiven the increased COVID-19 observed in kidney transplant recipients (KTRs) and haemodialysis patients, several studies have tried to...
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Dietary patterns, lung function and asthma in childhood: a longitudinal study
BackgroundLongitudinal epidemiological data are scarce examining the relationship between dietary patterns and respiratory outcomes in childhood. We...
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Successful rituximab treatment for severe rapidly progressive interstitial lung disease with anti-MDA5 antibody-positive juvenile dermatomyositis: a case report and literature review
BackgroundRapidly progressive (RP) interstitial lung disease (ILD) is a life-threatening complication of juvenile dermatomyositis (JDM); however, it...
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Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation
Liver transplantation is a highly complex and challenging field of clinical practice. Although it was originally developed in western countries, it...
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Neonatal injury models: integral tools to decipher the molecular basis of cardiac regeneration
Myocardial injury often leads to heart failure due to the loss and insufficient regeneration of resident cardiomyocytes. The low regenerative...
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Ellagic acid effects on testis, sex hormones, oxidative stress, and apoptosis in the relative sterility rat model following busulfan administration
BackgroundBusulfan is an antineoplastic medication that is broadly utilized for cancer treatment. It affects the testicular function and leads to...
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Idiopathic Aplastic anemia: Indian Perspective
Aplastic anemia (AA) is a rare immunologically mediated bone marrow failure syndrome, characterized by progressive loss of hematopoietic stem cells...
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Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure
Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of cardiac function by degrading cAMP and cGMP. In cardiomyocytes,...
