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Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study
Tumor-associated antigens (TAAs) are potential targets for T cell-based immunotherapy approaches in cutaneous melanoma. BNT111, an investigational...
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The point-of-care D-dimer test provides a fast and accurate differential diagnosis of Stanford Type A aortic syndrome and ST-elevated myocardial infarction in emergencies
BackgroundThe research of the sensitivity and specificity point-of-care testing (POCT) of D-dimer as a diagnostic protocol for differential diagnosis...
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SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence
Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating...
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Current advances and challenges in CAR T-Cell therapy for solid tumors: tumor-associated antigens and the tumor microenvironment
The past decade has witnessed ongoing progress in immune therapy to ameliorate human health. As an emerging technique, chimeric antigen receptor...
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Tissue and plasma proteomic profiling indicates AHSG as a potential biomarker for ascending thoracic aortic aneurysms
BackgroundThoracic Aortic Aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a...
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Awake intubation for thoracic aortic aneurysm causing esophageal stenosis with food residues and compression of the pulmonary artery and left bronchi: a case report
BackgroundAnesthetic management of thoracic aortic aneurysms (TAAs) is sometimes difficult due to fatal complications, including hypovolemic shock...
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Deep Learning-based Automated Aortic Area and Distensibility Assessment: the Multi-Ethnic Study of Atherosclerosis (MESA)
This study details application of deep learning for automatic segmentation of the ascending and descending aorta from 2D phase-contrast cine magnetic...
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Transforming Growth Factor-β and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment
Thoracic aortic aneurysms (TAAs) are permanent pathological dilatations of the thoracic aorta, which can lead to life-threatening complications, such...
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Determining the optimal interval for imaging surveillance of ascending aortic aneurysms
BackgroundCardiovascular guidelines recommend (bi-)annual computed tomography (CT) or magnetic resonance imaging (MRI) for surveillance of the...
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Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy
PurposeBispecific antibodies (BsAbs) have emerged as a leading drug class for cancer therapy and are becoming increasingly of interest for...
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Identification of apoptosis-related key genes and the associated regulation mechanism in thoracic aortic aneurysm
BackgroundThis study investigated the role of apoptosis-related genes in thoracic aortic aneurysms (TAA) and provided more insights into TAA's...
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Association of carotid ultrasonography with perioperative stroke after thoracic aortic aneurysm treatment: a retrospective study
PurposeThe purpose of this study was to verify whether carotid ultrasonography (CUS) findings could be associated with the occurrence of...
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Oncolytic measles virus therapy enhances tumor antigen-specific T-cell responses in patients with multiple myeloma
Oncolytic virus therapy leads to immunogenic death of virus-infected tumor cells and this has been shown in preclinical models to enhance the...
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Oncolytic viruses improve cancer immunotherapy by reprogramming solid tumor microenvironment
Immunotherapies using immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T-cell therapy have achieved successful results against...
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Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients
Tumor-associated antigens (TAAs) have been tested in various clinical trials in cancer treatment but the patterns of specific T cell response to...
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Feasibility of diabetes self-management coaching program for individuals with type 2 diabetes in the Ethiopian primary care setting: a protocol for a feasibility mixed-methods parallel-group randomized controlled trial
BackgroundDiabetes mellitus is the third most prevalent chronic metabolic disorder and a significant contributor to disability and impaired quality...
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Exploiting bacteria for cancer immunotherapy
Immunotherapy has revolutionized the treatment of cancer but continues to be constrained by limited response rates, acquired resistance, toxicities...
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Sex-related differences in outcome of thoracic aortic surgery
BackgroundSex-related dissimilarities’ influence on outcomes following thoracic aortic surgery is poorly understood. Our aim is to examine...
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Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours
Therapies with genetically modified T cells that express chimeric antigen receptors (CARs) specific for CD19 or B cell maturation antigen (BCMA) are...
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Long-term results of etiology-based thoracic endovascular aortic repair: a single-center experience
The use of thoracic endovascular aortic repair (TEVAR) for thoracic aortic aneurysm (TAA) and Stanford type B aortic dissection (TBAD) has been...
