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CancerGPT for few shot drug pair synergy prediction using large pretrained language models
Large language models (LLMs) have been shown to have significant potential in few-shot learning across various fields, even with minimal training...
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Understanding muscle coordination during gait based on muscle synergy and its association with symptoms in patients with knee osteoarthritis
ObjectiveWe aimed to investigate the muscle coordination differences between a control group and patients with mild and severe knee osteoarthritis...
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Synergy between ketamine and ketogenic diet in anorexia nervosa, and other neurobehavioral disorders
Through serendipity, we observed an apparent synergy between adopting a ketogenic diet and receiving ketamine infusions that led to complete and...
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Synergy-based functional electrical stimulation and robotic-assisted for retraining reach-to-grasp in stroke: a study protocol for a randomized controlled trial
BackgroundStroke survivors have long-term upper limb impairment, which impacts the quality of life (QOL) and social reintegration, but there is lack...
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Phytotherapeutic potential against MRSA: mechanisms, synergy, and therapeutic prospects
BackgroundRising resistance to antimicrobials, particularly in the case of methicillin-resistant Staphylococcus aureus (MRSA), represents a...
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Quantification of the Swallowing Mechanism Through Muscle Synergy Analysis
Decreased swallowing function increases the risk of choking and aspiration pneumonia. Videofluoroscopy and computed tomography allow for detailed...
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The relationship between chronic disease and drugs/toxins—how important is negative disease-drug synergy?
The interaction of diseases with drugs and toxins may result in significantly worse outcomes in a forensic context when i) chronic diseases cause...
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Palliative Care Psychiatry: Building Synergy Across the Spectrum
Purpose of ReviewPalliative care (PC) psychiatry is a growing subspecialty focusing on improving the mental health of those with serious medical...
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Efficacy and safety of the combination of tranexamic acid injection and electro-optical synergy (ELOS) versus tranexamic acid injection alone in the treatment of melasma
Melasma is a common, relapsing, multifactorial disease for which the treatment decision remains extremely difficult. This study was designed to...
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Drug research and development opportunities in low- and middle-income countries: accelerating traditional medicine through systematic utilization and comprehensive synergy
BackgroundThough the utilization of traditional medicine has been proposed for modern drug research and development (R&D), limited research has...
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Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities
Myasthenia gravis is an autoimmune disorder defined by muscle weakness and fatigability associated with antibodies against proteins of the...
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Unraveling the synergy: how organizational intelligence fuel soft skills and nurses’ thriving: a cross-sectional study
AimInvestigate the influence of organizational intelligence on the development of soft skills and the overall thriving of nurses at Alexandria Main...
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Unilateral symptomatic Achilles tendinopathy has limited effects on bilateral lower limb ground reaction force asymmetries and muscular synergy attributes when walking at natural and fast speeds
BackgroundAchilles tendinopathy (AT) may affect ground reaction force (GRF) and muscle synergy (MS) during walking due to pain, biological integrity...
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Elucidating molecular mechanisms and therapeutic synergy: irreversible HER2-TKI plus T-Dxd for enhanced anti-HER2 treatment of gastric cancer
BackgroundHER2-targeted therapies have improved the outcomes of HER2-positive gastric cancer (GC), yet resistance remains a challenge. We sought to...
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Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19
Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system. In contrast,...
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7 T and beyond: toward a synergy between fMRI-based presurgical map** at ultrahigh magnetic fields, AI, and robotic neurosurgery
Presurgical evaluation with functional magnetic resonance imaging (fMRI) can reduce postsurgical morbidity. Here, we discuss presurgical fMRI...
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Diagnostic and societal impact of implementing the syncope guidelines of the European Society of Cardiology (SYNERGY study)
BackgroundSyncope management is fraught with unnecessary tests and frequent failure to establish a diagnosis. We evaluated the potential of...
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Enhanced anticancer synergy of LOM612 in combination with selinexor: FOXO1 nuclear translocation-mediated inhibition of Wnt/β-catenin signaling pathway in breast cancer
BackgroundThe intricate relationship between Forkhead box O1 (FOXO1), a well-established tumor suppressor, and breast cancer (BC) remains partially...
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Dual-task versus single-task gait rehabilitation after stroke: the protocol of the cognitive-motor synergy multicenter, randomized, controlled superiority trial (SYNCOMOT)
BackgroundGait disorders and cognitive impairments are prime causes of disability and institutionalization after stroke. We hypothesized that...
