Search
Search Results
-
Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling
The growth cone guides the axon or dendrite of striatal GABAergic projection neurons that protrude into the midbrain and cortex and form complex...
-
-
Thyroxine restores hippocampal neurogenesis and synaptogenesis in a male rat model of carbimazole-induced hypothyroidism: a histological study
BackgroundAdult-onset hypothyroidism has a deleterious effect on hippocampal cognitive and memory functions. This study was performed to evaluate the...
-
Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline
Lysergic acid diethylamide (LSD) is a serotonergic psychedelic compound receiving increasing interest due to putative anxiolytic and antidepressant...
-
-
A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets
Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the mechanisms that may underlie its anti-addictive effects...
-
Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder
BackgroundDefects in neurotransmission and synaptogenesis are noteworthy in the pathogenesis of ASD. Synapsin III (SYN III) is defined as a synaptic...
-
Identification of circRNA–miRNA–mRNA regulatory network associated to the autism spectrum disorder in children through integrated bioinformatics analysis
BackgroundAutism spectrum disorder (ASD) is a complex neurological disability with multifactorial etiology. ASD is described by behavior, speech,...
-
Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances
Background/ObjectiveAnorexigenic palmitoylated prolactin-releasing peptide (palm 11 -PrRP) is able to act centrally after peripheral administration in...
-
Neuroprotective and neuroregenerative drugs after severe traumatic brain injury
Traumatic brain injuries cause enormous individual and socioeconomic burdens. Survivors frequently struggle with motor handicaps as well as impaired...
-
Towards an understanding of psychedelic-induced neuroplasticity
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and...
-
Impact of alcohol exposure on neural development and network formation in human cortical organoids
Prenatal alcohol exposure is the foremost preventable etiology of intellectual disability and leads to a collection of diagnoses known as Fetal...
-
Autism-associated gene shank3 is necessary for social contagion in zebrafish
BackgroundAnimal models enable targeting autism-associated genes, such as the shank3 gene, to assess their impact on behavioural phenotypes....
-
An epigenetic mechanism for over-consolidation of fear memories
Excessive fear is a hallmark of anxiety disorders, a major cause of disease burden worldwide. Substantial evidence supports a role of prefrontal...
-
Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
AbstractThe hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory,...
-
CDKL5 deficiency-related neurodevelopmental disorders: a multi-center cohort study in Italy
CDKL5 deficiency disorder (CDD) is a complex clinical condition resulting from non-functional or absent CDKL5 protein, a serine–threonine kinase...
-
Synaptic and mitochondrial mechanisms behind alcohol-induced imbalance of excitatory/inhibitory synaptic activity and associated cognitive and behavioral abnormalities
Alcohol consumption during pregnancy can significantly impact the brain development of the fetus, leading to long-term cognitive and behavioral...
-
Methadone alters transcriptional programs associated with synapse formation in human cortical organoids
Opioid use disorder (OUD) among pregnant women has become an epidemic in the United States. Pharmacological interventions for maternal OUD most...
-
Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus
Severe psychiatric illnesses, for instance schizophrenia, and affective diseases or autism spectrum disorders, have been associated with cognitive...
-
Imaging synaptic density in depression
Major depressive disorder is a prevalent and heterogeneous disorder with treatment resistance in at least 50% of individuals. Most of the initial...
