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Loss of microglial EED impairs synapse density, learning, and memory
The embryonic ectoderm development (EED) is a core component of the polycomb-repressive complex 2 (PRC2) whose mutations are linked to...
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The synapse as a treatment avenue for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder with devastating symptoms, including memory impairments and cognitive deficits. Hallmarks of...
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Perineuronal nets affect memory and learning after synapse withdrawal
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have...
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SARS-CoV-2 promotes microglial synapse elimination in human brain organoids
Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are...
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Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences
Chronic unpredictable stress (CUS) drives microglia-mediated neuronal remodeling and synapse loss in the prefrontal cortex (PFC), contributing to...
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Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior
The Wnt/β-catenin pathway contains multiple high-confidence risk genes that are linked to neurodevelopmental disorders, including autism spectrum...
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A whole transcriptome profiling analysis for antidepressant mechanism of **aoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats
BackgroundDepression is a neuropsychiatric disease resulting from deteriorations of molecular networks and synaptic injury induced by stress....
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Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule
Dysregulated neurite outgrowth and synapse formation underlie many psychiatric disorders, which are also manifested by wolfram syndrome (WS). Whether...
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Integrative analysis of long noncoding RNAs dysregulation and synapse-associated ceRNA regulatory axes in autism
Autism spectrum disorder (ASD) is a complex disorder of neurodevelopment, the function of long noncoding RNA (lncRNA) in ASD remains essentially...
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Fluid markers of synapse degeneration in synucleinopathies
The abnormal accumulation of α-synuclein in the brain is a common feature of Parkinson’s disease (PD), PD dementia (PDD), dementia with Lewy bodies...
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Methadone alters transcriptional programs associated with synapse formation in human cortical organoids
Opioid use disorder (OUD) among pregnant women has become an epidemic in the United States. Pharmacological interventions for maternal OUD most...
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Cylindromatosis drives synapse pruning and weakening by promoting macroautophagy through Akt-mTOR signaling
The lysine-63 deubiquitinase cylindromatosis (CYLD) is long recognized as a tumor suppressor in immunity and inflammation, and its loss-of-function...
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Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer’s disease-like mouse model
Passive immunotherapy is one of the most promising interventions for Alzheimer’s disease (AD). However, almost all immune-modulating strategies fail...
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Glutamatergic synapse in autism: a complex story for a complex disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathophysiological mechanisms are still unclear. Hypotheses suggest a role for...
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Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia
Our previous study data suggested that the synapse-associated protein 97 (SAP97) rs3915512 polymorphism is significantly related to clinical...
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CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells
Bispecific T-cell engager (BiTE ® ) molecules recruit T cells to cancer cells through CD3ε binding, independently of T-cell receptor (TCR) specificity....
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Adolescent social isolation induces distinct changes in the medial and lateral OFC-BLA synapse and social and emotional alterations in adult mice
Early-life social isolation is associated with social and emotional problems in adulthood. However, neural mechanisms underlying how social...
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A novel circular RNA, circIgfbp2, links neural plasticity and anxiety through targeting mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after traumatic brain injury
Traumatic brain injury (TBI) can lead to different neurological and psychiatric disorders. Circular RNAs (circRNAs) are highly expressed in the...
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ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity
The precise control of the nervous system function under the vitality of synapses is extremely critical. Efforts have been taken to explore the...
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Molecular pathways of major depressive disorder converge on the synapse
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular...
