Search
Search Results
-
Murine myeloid derived suppressor cells possess a range of suppressive mechanisms—Granzyme B is not among them
This paper addresses the controversy of Granzyme B (GzmB) expression by murine Myeloid Derived Suppressor Cells (MDSCs). MDSCs are a heterogenous...
-
Myeloid-derived suppressor cells in cancer and cancer therapy
Anticancer agents continue to dominate the list of newly approved drugs, approximately half of which are immunotherapies. This trend illustrates the...
-
Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
Myeloid-derived suppressor cells (MDSCs), major components maintaining the immune suppressive microenvironment in lung cancer, are relevant to the...
-
Tumor-associated myeloid cells in cancer immunotherapy
Tumor-associated myeloid cells (TAMCs) are among the most important immune cell populations in the tumor microenvironment, and play a significant...
-
FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion
BackgroundEmerging evidences suggest that aberrant metabolites contributes to the immunosuppressive microenvironment that leads to cancer immune...
-
Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-ligand 1, and cytotoxic T-lymphocyte-associated protein 4...
-
Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion
Paradoxically, tumor development and progression can be inhibited and promoted by the immune system. After three stages of immune editing, namely,...
-
CD45 inhibition in myeloid leukaemia cells sensitizes cellular responsiveness to chemotherapy
Myeloid malignancies are a group of blood disorders characterized by the proliferation of one or more haematopoietic myeloid cell lineages,...
-
Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells
Myeloid-derived suppressor cells (MDSCs) are bone marrow (BM)-derived immunosuppressive cells in the tumor microenvironment, but the mechanism of...
-
Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate
STING is a pivotal mediator of effective innate and adaptive anti-tumor immunity; however, intratumoral administration of STING agonists have shown...
-
The role of myeloid-derived suppressor cells in liver cancer
MDSCs are immature myeloid immune cells, which accumulate in models of liver cancer to reduce effector immune cell activity, contribute to immune...
-
Inflammatory recruitment of healthy hematopoietic stem and progenitor cells in the acute myeloid leukemia niche
Inflammation in the bone marrow (BM) microenvironment is a constitutive component of leukemogenesis in acute myeloid leukemia (AML). Current evidence...
-
Hepatic recruitment of myeloid-derived suppressor cells upon liver injury promotes both liver regeneration and fibrosis
BackgroundThe liver regeneration is a highly complicated process depending on the close cooperations between the hepatocytes and non-parenchymal...
-
The prognostic effects of circulating myeloid-derived suppressor cells in non-small cell lung cancer: systematic review and meta-analysis
Immunotherapy is the main standard treatment for non-small cell lung cancer (NSCLC) patients. Immune suppressive cells in tumor microenvironment can...
-
Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells
Myeloid-derived suppressor cells (MDSCs) were found to gradually accumulate in the orthotopic esophageal cancer mouse model during tumor progression....
-
Blockade of Myd88 signaling by a novel MyD88 inhibitor prevents colitis-associated colorectal cancer development by impairing myeloid-derived suppressor cells
Background. In cancer, myeloid-derived suppressor cells (MDSCs) are known to escape the host immune system by develo** a highly suppressive...
-
Monocytic myeloid-derived suppressor cells as an immune indicator of early diagnosis and prognosis in patients with sepsis
BackgroundImmunosuppression is a leading cause of septic death. Therefore, it is necessary to search for biomarkers that can evaluate the immune...
-
Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3β Signaling Pathway
ObjectiveTo investigate the role of ginsenoside Rd (GRd) in acute myeloid leukemia (AML) cell differentiation.
MethodsAML cells were treated with...
-
HIV-1 Myeloid Reservoirs — Contributors to Viral Persistence and Pathogenesis
Purpose of ReviewHIV reservoirs are the main barrier to cure. CD4+ T cells have been extensively studied as the primary HIV-1 reservoir. However,...
-
Epigenetic regulation by ASXL1 in myeloid malignancies
Myeloid malignancies are clonal hematopoietic disorders that are comprised of a spectrum of genetically heterogeneous disorders, including...
