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The association of SOD and HsCRP with the efficacy of sulforaphane in schizophrenia patients with residual negative symptoms
ObjectivesEmerging evidence indicates a connection between oxidative stress, immune-inflammatory processes, and the negative symptoms of...
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Sulforaphane Does Not Protect Right Ventricular Systolic and Diastolic Functions in Nrf2 Knockout Pulmonary Artery Hypertension Mice
PurposeNrf2 is a nuclear transcription factor and plays an important role in the regulation of oxidative stress and inflammation. We recently...
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Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway
BackgroundChimeric antigen receptor T (CAR-T) cell therapy has limited effects in the treatment of solid tumors. Sulforaphane (SFN) is known to play...
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Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension
Sulforaphane, an isothiocyanate found in cruciferous vegetables such as broccoli, shows promise as an adjuvant therapy for preeclampsia. To inform...
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Immunoregulatory and/or Anti-inflammatory Agents for the Management of Core and Associated Symptoms in Individuals with Autism Spectrum Disorder: A Narrative Review of Randomized, Placebo-Controlled Trials
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with a so far poorly understood underlying pathogenesis, and few...
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Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment
Tumorigenicity-inhibiting compounds have been identified in our daily diet. For example, isothiocyanates (ITCs) found in cruciferous vegetables were...
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Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice
The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia from the lateral habenula (LHb) reportedly induces...
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TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition
Cancer stem cells (CSCs) have an established role in cancer progression and therapeutic resistance. The p63 proteins are important transcription...
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Glucosinolates in cancer prevention and treatment: experimental and clinical evidence
Glucosinolates are naturally occurring β-d-thioglucosides that mainly exist in the Brassicaceae family. The enzyme myrosinase hydrolyzes...
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Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
Estrogen receptor (ER) positive breast cancer is frequently sensitive to endocrine therapy. Multiple mechanisms of endocrine therapy resistance have...
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Nutrition, Immunology, and Kidney: Looking Beyond the Horizons
Purpose of ReviewChronic kidney disease (CKD) is epidemic throughout the word. Despite various novel therapeutic opportunities, CKD is still...
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Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents
The transcription factor erythroid 2-related factor 2 (Nrf2) and brain-derived neurotrophic factor (BDNF) play a key role in depression. However, the...
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Novel molecules as the emerging trends in cancer treatment: an update
As per World Health Organization cancer remains as a leading killer disease causing nearly 10 million deaths in 2020. Since the burden of cancer...
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Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration
BackgroundIntervertebral disc (IVD) is a highly rhythmic tissue, which experiences a diurnal cycle of high/low mechanical loading via the changes of...
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Decoding the interaction between miR-19a and CBX7 focusing on the implications for tumor suppression in cancer therapy
Cancer is a complex and multifaceted disease characterized by uncontrolled cell growth, genetic alterations, and disruption of normal cellular...
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18β-glycyrrhetinic acid suppresses Lewis lung cancer growth through protecting immune cells from ferroptosis
Purpose18β-glycyrrhetinic acid (GA), the main metabolite of glycyrrhizic acid extracted from the root of licorice, has been reported to possess...
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Diabetes-induced chronic heart failure is due to defects in calcium transporting and regulatory contractile proteins: cellular and molecular evidence
Heart failure (HF) is a major deteriorating disease of the myocardium due to weak myocardial muscles. As such, the heart is unable to pump blood...
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Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma
Melanoma is an aggressive skin cancer with increasing incidence rates globally. On the other hand, isothiocyanates are derived from cruciferous...
