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Type 2 diabetes and succinate: unmasking an age-old molecule
Beyond their conventional roles in intracellular energy production, some traditional metabolites also function as extracellular messengers that...
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Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts
A hallmark of heart failure is a metabolic switch away from fatty acids β-oxidation (FAO) to glycolysis. Here, we show that succinate dehydrogenase...
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Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3
To investigate the effect of Oncometabolite succinate on colorectal cancer migration and invasion and to initially explore the underlying...
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Application of metabolomics in urolithiasis: the discovery and usage of succinate
Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. It has been shown that the occurrence of...