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Sublingual Dexmedetomidine for Agitation Associated with Schizophrenia or Bipolar Disorder: A Post Hoc Analysis of Number Needed to Treat, Number Needed to Harm, and Likelihood to be Helped or Harmed
IntroductionThe objective was to use the evidence-based medicine metrics of number needed to treat, number needed to harm, and likelihood to be...
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Epidural nalbuphine versus dexmedetomidine as adjuvants to bupivacaine in lower limb orthopedic surgeries for postoperative analgesia: a randomized controlled trial
BackgroundAdministration of adjuvant drugs epidurally in combination with local anesthetics offers new dimensions in the management of postoperative...
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Methadone in combination with magnesium, ketamine, lidocaine, and dexmedetomidine improves postoperative outcomes after coronary artery bypass grafting: an observational multicentre study
BackgroundAn optimal pharmacological strategy for fast-track cardiac anesthesia (FTCA) is unclear. This study evaluated the effectiveness and safety...
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Effect of erector spinae plane block with different doses of dexmedetomidine as adjuvant for ropivacaine on the postoperative quality of recovery after video-assisted thoracoscopic lobectomy surgery: a randomized controlled trial
BackgroundErector spinae plane block (ESPB) improves postoperative analgesia and significantly enhances the quality of recovery (QoR) after...
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Efficacy and safety of intranasal ketamine compared with intranasal dexmedetomidine as a premedication before general anesthesia in pediatric patients: a systematic review and meta-analysis of randomized controlled trials
PurposeTo compare the efficacy and safety of intranasal ketamine with intranasal dexmedetomidine as a premedication in pediatric patients undergoing...
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A Review of Sublingual Sufentanil Tablet (SST) and its Utility as an Analgesic Agent for Pain Procedures
Purpose of ReviewSedation for pain medicine procedures provides a unique challenge for proceduralists. Many patients dealing with pain are on chronic...
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Reno-protective effects of perioperative dexmedetomidine in kidney transplantation: a systematic review and meta-analysis of randomized controlled trials
Background and objectiveThere is currently no FDA-approved medical therapy for delayed graft function (DGF). Dexmedetomidine (DEX) has multiple...
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Opioid-free anesthesia for patients with joint hypermobility syndrome undergoing craneo-cervical fixation: a case-series study focused on anti-hyperalgesic approach
BackgroundPatients with Ehlers-Danlos Syndrome/Hypermobility Type (EDS-HT/JHS) and Craneo-Cervical Instability frequently suffer from severe...
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Methodical control of the difficult pediatric airway: two case reports
BackgroundManagement of children who present with a history of impossible mask ventilation or difficult tracheal intubation is fraught with...
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Transdermal Low-Dose Buprenorphine Induction to Transition a Patient off a Higher-Dose Methadone Regimen: a Case Report
Buprenorphine is a partial μ‐opioid agonist with high receptor binding affinity and long half-life—qualities that reduce overdose risk with...
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Medication errors related to high-alert medications in a paediatric university hospital – a cross-sectional study analysing error reporting system data
BackgroundPaediatric patients are prone to medication errors, and only a few studies have explored errors in high-alert medications in children. The...
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Patients on Buprenorphine Formulations Undergoing Surgery
Purpose of ReviewTo review the pharmacology of buprenorphine, the evolution of buprenorphine dosing recommendations, and the current literature...
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Perioperative opioid requirements of patients receiving sublingual buprenorphine-naloxone: a case series
BackgroundBuprenorphine, a partial opioid agonist, displaces full opioid agonists from receptors and may impede surgical pain management. We report...
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ERAS Protocol Options for Perioperative Pain Management of Substance Use Disorder in the Ambulatory Surgical Setting
AbstractEven prior to the COVID-19 pandemic, rates of ambulatory surgeries and ambulatory patients presenting with substance use disorder were...
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Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines
BackgroundNon-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous...
