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Deep learning model for predicting the presence of stromal invasion of breast cancer on digital breast tomosynthesis
To develop a deep learning (DL)-based algorithm to predict the presence of stromal invasion in breast cancer using digital breast tomosynthesis...
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Mesenchymal stromal cells confer breast cancer doxorubicin resistance by producing hyaluronan
Chemotherapy resistance represents a major cause of therapeutic failure and mortality in cancer patients. Mesenchymal stromal cells (MSCs), an...
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Stromal grading predicts pathologic complete response and prognosis in triple-negative breast cancer
Do traditional prognostic factors fully account for the diversity of clinical behavior in breast cancer? Triple-negative breast cancer (TNBC) is an...
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Periductal Stromal Tumor of Vulva: An Extremely Rare Entity
BackgroundEctopic breast tissue on vulva is extremely rare. It can give rise to both benign and malignant lesions but these cases are very uncommon.
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Breast tissue imaging atlas using ultra-fast confocal microscopy to identify cancer lesions
New generation ultra-fast fluorescence confocal microscopy (UFCM) allows to image histological architecture of fresh breast tissue and may be used...
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Automated quantification of stromal tumour infiltrating lymphocytes is associated with prognosis in breast cancer
Stromal tumour infiltrating lymphocytes (sTIL) in haematoxylin and eosin (H&E) stained sections has been linked to better outcomes and better...
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Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary Carcinomas
Cancer-associated stroma (CAS) is widely recognized to influence development and progression of epithelial tumours including breast cancer. Canine...
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Fibroadenoma in axillary accessory breast tissue: a case report
BackgroundAccessory breast(s) is defined as the presence of more than two breasts with or without a nipple and areola in human beings. It may occur...
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Cosmetic Breast Augmentation with Autologous Ex Vivo-Expanded Adipose-Derived Mesenchymal Stem/Stromal Cell (Stemform®)-Enriched Fat Grafts: A Study of the First Twenty-Two Real-World Patients
BackgroundFat grafting is commonly utilized in breast surgery, and since it was first described, clinicians and researchers have stridden towards...
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Intraoperative Intradermal Application of Stromal Vascular Fraction into the Abdominal Suture Line: Histological Analysis of Abdominal Scar Tissue
BackgroundStem cell therapy is a promising new approach to wound healing. Stromal vascular fraction is a heterogeneous collection of cells, including...
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Evaluation of blood supply and metabolism in tumor, axillary lymph node and normal breast tissue with F-18 FDG PET/CT in breast cancer: comparison with pathological prognostic factors
Background and purposePerfusion parameters obtained in F-18 FDG PET/CT performed for staging purposes in breast cancers may provide additional...
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Stromal Changes are Associated with High P4HA2 Expression in Ductal Carcinoma in Situ of the Breast
Ductal carcinoma in situ (DCIS) of the breast is able to induce stromal changes, which likely reflect the crosstalk between DCIS and its...
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The role of stromal cells in epithelial–mesenchymal plasticity and its therapeutic potential
The epithelial–mesenchymal transition (EMT) is a critical tumor invasion and metastasis process. EMT enables tumor cells to migrate, detach from...
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The effect of mesenchymal stromal cells ın the microenvironment on cancer development
Inflammatory signals secreted from the tumor microenvironment are thought to promote tumor growth and survival. It has been reported that stromal...
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Effects of metformin on human bone-derived mesenchymal stromal cell—breast cancer cell line interactions
Metformin is used to treat patients with type 2 diabetes mellitus and was found to lower the incidence of cancer. Bone metastasis is a common...
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Revisiting the role of mesenchymal stromal cells in cancer initiation, metastasis and immunosuppression
Immune checkpoint blockade (ICB) necessitates a thorough understanding of intricate cellular interactions within the tumor microenvironment (TME)....
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STIM1/SOX2 proteins are co-expressed in the tumor and microenvironmental stromal cells of pancreatic ductal adenocarcinoma and ampullary carcinoma
Pancreatic ductal adenocarcinoma (PDAC) and ampullary carcinoma (AAC) are lethal malignancies with modest benefits from surgery. SOX2 and STIM1 have...
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Integrin regulation by tissue factor promotes cancer stemness and metastatic dissemination in breast cancer
Tissue Factor (TF) is the initiator of blood coagulation but also functions as a signal transduction receptor. TF expression in breast cancer is...
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Transforming growth factor-induced gene TGFBI is correlated with the prognosis and immune infiltrations of breast cancer
BackgroundTransforming growth factor β (TGFβ) is a critical regulator of lung metastasis of breast cancer and is correlated with the prognosis of...
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A novel preclinical model of the normal human breast
Improved screening and treatment have decreased breast cancer mortality, although incidence continues to rise. Women at increased risk of breast...
