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Recommendations for robust and reproducible preclinical research in personalised medicine
BackgroundPersonalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of...
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Representations of personalised medicine in family medicine: a qualitative analysis
BackgroundThe promise of personalised medicine (PM) to transform healthcare has sparked great enthusiasm in the last years. Yet, its lack of...
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A functional personalised oncology approach against metastatic colorectal cancer in matched patient derived organoids
Globally, colorectal cancer (CRC) is the third most frequently occurring cancer. Progression on to an advanced metastatic malignancy (metCRC) is...
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Develo** tailored intervention strategies for implementation of stratified care to low back pain with physiotherapists in Nigeria: a Delphi study
BackgroundStratified care approach involving use of the STarT-Back tool to optimise care for patients with low back pain is gaining widespread...
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Guidance for the Harmonisation and Improvement of Economic Evaluations of Personalised Medicine
ObjectiveThe objective of this study was to develop guidance contributing to improved consistency and quality in economic evaluations of personalised...
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Diabetes precision medicine: plenty of potential, pitfalls and perils but not yet ready for prime time
Rapid advances in technology and data science have the potential to improve the precision of preventive and therapeutic interventions, and enable the...
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Stratified distribution of Th17 and Treg cells in patients with multi-stage rheumatoid arthritis
ObjectiveRheumatoid arthritis (RA) is a typical, progressive autoimmune disease. Its occurrence and development are associated with dysregulation of...
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Personalised rehabilitation to improve return to work in patients with persistent spinal pain syndrome type II after spinal cord stimulation implantation: a study protocol for a 12-month randomised controlled trial—the OPERA study
BackgroundFor patients with therapy-refractory persistent spinal pain syndrome type II (PSPS-T2), spinal cord stimulation (SCS) may serve as an...
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Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock—a two-centre randomised clinical trial
BackgroundAdequate antibiotic dosing may improve outcomes in critically ill patients but is challenging due to altered and variable pharmacokinetics....
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NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients
NAVIGATOR is an Italian regional project boosting precision medicine in oncology with the aim of making it more predictive, preventive, and...
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Progress to Date in Advancing Stratified Medicine in Psoriasis
Stratified medicine is the tailoring of treatment to the individual characteristics of each patient. This is a challenging task in the context of...
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Tools for the Economic Evaluation of Precision Medicine: A Sco** Review of Frameworks for Valuing Heterogeneity-Informed Decisions
Background and ObjectivePrecision medicine highlights the importance of exploring heterogeneity in the effectiveness and costs of interventions. Our...
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Engineering prostate cancer in vitro: what does it take?
A key challenge in the clinical management and cause of treatment failure of prostate cancer (PCa) is its molecular, cellular and clinical...
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A pragmatic randomised controlled trial referring to a Personalised Self-management SUPport Programme (P-SUP) for persons enrolled in a disease management programme for type 2 diabetes mellitus and/or for coronary heart disease
BackgroundType 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) are two chronic diseases that cause a tremendous burden. To reduce this...
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The Interface of Therapeutics and Genomics in Cardiovascular Medicine
Pharmacogenomics has a burgeoning role in cardiovascular medicine, from warfarin dosing to antiplatelet choice, with recent developments in...
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Lifestyle interventions in pregnancy targeting GDM prevention: looking ahead to precision medicine
Gestational diabetes mellitus (GDM) is the most prevalent pregnancy-related endocrinopathy, affecting up to 25% of pregnancies worldwide. Pregnant...
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Towards Personalising the Use of Biologics in Rheumatoid Arthritis: A Discrete Choice Experiment
IntroductionThere have been promising developments in technologies and associated algorithm-based prescribing (‘stratified approach’) to target...
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Adapting the randomised controlled trial (RCT) for precision medicine: introducing the nested-precision RCT (npRCT)
Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To...
