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Appropriate medication use in Dutch terminal care: study protocol of a multicentre stepped-wedge cluster randomized controlled trial (the AMUSE study)
BackgroundPolypharmacy is common among patients with a limited life expectancy, even shortly before death. This is partly inevitable, because these...
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The POP (Permanent Supportive Housing Overdose Prevention) Study: protocol for a hybrid type 3 stepped-wedge cluster randomized controlled trial
BackgroundPermanent supportive housing (PSH)—subsidized housing paired with support services such as case management—is a key part of national...
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Implementation of an evidence-based management algorithm for patients with chronic pancreatitis (COMBO trial): study protocol for a stepped-wedge cluster-randomized controlled trial
BackgroundChronic pancreatitis (CP) is an inflammatory disease that may be complicated by abdominal pain, pancreatic dysfunction, nutritional...
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Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial
BackgroundIn critically ill patients, positive fluid balance is associated with excessive mortality. The POINCARE-2 trial aimed to assess the...
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Effectiveness of a Population Health Intervention on Disparities in Hypertension Control: A Stepped Wedge Cluster Randomized Clinical Trial
BackgroundDisparities in hypertension control across race, ethnicity, and language have been a long-standing problem in the United States.
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Design and rationale of the Botswana Smoking Abstinence Reinforcement Trial: a protocol for a stepped-wedge cluster randomized trial
BackgroundWith expanded and sustained availability of HIV treatment resulting in substantial improvements in life expectancy, the need to address...
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Effect of a Predictive Analytics-Targeted Program in Patients on Opioids: a Stepped-Wedge Cluster Randomized Controlled Trial
BackgroundRisk of overdose, suicide, and other adverse outcomes are elevated among sub-populations prescribed opioid analgesics. To address this, the...
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A multicomponent intervention program to Prevent and Reduce AgItation and phySical rEstraint use in the ICU (PRAISE): study protocol for a multicenter, stepped-wedge, cluster randomized controlled trial
BackgroundPhysical restraints remain to be commonly used in agitated intensive care unit (ICU) patients worldwide, despite a lack of evidence on...
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Effect evaluation of a tele-neurologic intervention in primary care in a rural area in Germany—the NeTKoH study protocol of a stepped-wedge cluster randomized trial
BackgroundNeurological disorders account for a large and increasing proportion of the global burden of disease. Therefore, it is important to...
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Impact of a multifaceted early mobility intervention for critically ill children — the PICU Up! trial: study protocol for a multicenter stepped-wedge cluster randomized controlled trial
BackgroundOver 50% of all critically ill children develop preventable intensive care unit-acquired morbidity. Early and progressive mobility is...
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Enhancing doctor-patient relationships in community health care institutions: the Patient Oriented Four Habits Model (POFHM) trial—a stepped wedge cluster randomized trial protocol
BackgroundThe poor relationship between doctors and patients is a long-standing, global problem. However, current interventions tend to focus on the...
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Effect of the 1-h bundle on mortality in patients with suspected sepsis in the emergency department: a stepped wedge cluster randomized clinical trial
PurposeThe efficacy of the 1-h bundle for emergency department (ED) patients with suspected sepsis, which includes lactate measurement, blood...
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The protocol of Enhanced Recovery After Cardiac Surgery (ERACS) in congenital heart disease: a stepped wedge cluster randomized trial
BackgroundThe Enhanced Recovery After Cardiac Surgery (ERACS) programs are comprehensive multidisciplinary interventions to improve patients’...
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Depression and loneliness among Sub-Saharan immigrants living in the greater Paris area: results from the MAKASI empowerment stepped wedge cluster randomised controlled trial
PurposeThe MAKASI intervention aimed to empower Sub-Saharan African immigrants living in precarious situations in the Paris metropolitan area....
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Supporting ColoREctal Equitable Navigation (SCREEN): a protocol for a stepped-wedge cluster randomized trial for patient navigation in primary care
BackgroundBlack individuals in the United States (US) have a higher incidence of and mortality from colorectal cancer (CRC) compared to other racial...
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Evaluation of a community-based integrated care model (CIE) for frail older people in rural Foshan, China: study protocol for a stepped-wedge cluster randomized controlled trial {1}
BackgroundWhile community-based eldercare has proven to be effective in qualitative studies, there is limited evidence on the effectiveness of this...
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Systems analysis and improvement approach to optimize tuberculosis (SAIA-TB) screening, treatment, and prevention in South Africa: a stepped-wedge cluster randomized trial
BackgroundThe use of systems engineering tools, including the development and use of care cascades using routinely collected data, process map**,...
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PLUS-IS-LESS project: Procalcitonin and Lung UltraSonography-based antibiotherapy in patients with Lower rESpiratory tract infection in Swiss Emergency Departments: study protocol for a pragmatic stepped-wedge cluster-randomized trial
BackgroundLower respiratory tract infections (LRTIs) are among the most frequent infections and a significant contributor to inappropriate antibiotic...
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Comparing analytical strategies for balancing site-level characteristics in stepped-wedge cluster randomized trials: a simulation study
BackgroundStepped-wedge cluster randomized trials (SWCRTs) are a type of cluster-randomized trial in which clusters are randomized to cross-over to...
