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Low-density lipoprotein cholesterol reduction with immediate combination therapy of statin and ezetimibe compared to statin monotherapy after percutaneous coronary intervention
BackgroundCurrent guidelines recommend a stepwise initiation of lipid-lowering therapy after percutaneous coronary interventions (PCI) in...
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Comparative Safety and Efficacy of Low/Moderate-Intensity Statin plus Ezetimibe Combination Therapy vs. High-Intensity Statin Monotherapy in Patients with Atherosclerotic Cardiovascular Disease: An Updated Meta-Analysis
AimStatin therapy is considered the gold standard for treating hypercholesterolemia. This updated meta-analysis aims to compare the efficacy and...
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Statin therapy improves outcomes in infective endocarditis: evidence from a meta-analysis
BackgroundBeyond its ability to decrease cholesterol, statin medication has been proved to have a variety of pleiotropic effects, such as...
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Effect of statin therapy patterns on readmission and mortality in patients with intracerebral hemorrhage
There is limited and inconsistent evidence for the association of statin therapy and statin treatment patterns with the risk of recurrent...
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Strategies aiming to improve statin therapy adherence in older adults: a systematic review
BackgroundRandomized clinical trials have shown that, under optimal conditions, statins reduce the risk of cardiovascular events in older adults....
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Risk and effect modifiers for poor glycemic control among the chinese diabetic adults on statin therapy: the kailuan study
BackgroundLimited studies have investigated the association between statin therapy and poor glycemic control, especially in the Chinese diabetic...
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Updates on Non-Statin LDL-Lowering Therapy
Purpose of ReviewThere is ample evidence of the benefits and safety of low-density lipoprotein (LDL)-lowering therapies in the prevention of...
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Association of statin use after renal replacement therapy with mortality in patients with dialysis-requiring acute kidney injury
BackgroundStatin use before hospitalization or after discharge increased the survival rates of patients with dialysis-requiring acute kidney injury....
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Association of statin therapy with progression of carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis (MESA)
Arterial stiffness progresses with age and is a predictor of adverse cardiovascular disease events. Studies examining associations of statin therapy...
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A mobile health application for patients eligible for statin therapy: app development and qualitative feedback on design and usability
BackgroundCardiovascular disease is the leading cause of death in the United States (US). Despite the well-recognized efficacy of statins, statin...
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Endothelin-1 is associated with mortality that can be attenuated with high intensity statin therapy in patients with stable coronary artery disease
BackgroundAll coronary artery disease (CAD) patients do not benefit equally of secondary prevention. Individualized intensity of drug therapy is...
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Statin Intolerance: an Overview of US and International Guidance
Purpose of ReviewTo review recent international and domestic definitions, considerations, and treatment algorithms for statin intolerance, and...
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The Role of Mitochondria in Statin-Induced Myopathy
Statins represent the primary therapy for combatting hypercholesterolemia and reducing mortality from cardiovascular events. Despite their...
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Association between circulatory microRNA-218 expression, serum PCSK9 levels, inflammatory markers, and monocyte subsets in coronary artery disease patients: impact of statin therapy
BackgroundProprotein convertase subtilisin/kexin type-9 (PCSK9), an enzyme produced mainly by hepatocytes and breaks low-density lipoprotein receptor...
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Effect of an increase in Lp(a) following statin therapy on cardiovascular prognosis in secondary prevention population of coronary artery disease
BackgroundLipoprotein (a) [Lp(a)] is an independent risk factor for coronary artery disease (CAD). Recent studies have indicated that statins tend to...
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Relative contributions of statin intensity, achieved low-density lipoprotein cholesterol level, and statin therapy duration to cardiovascular risk reduction in patients with type 2 diabetes: population based cohort study
BackgroundCurrent guidelines recommend life-long use of statin for patients with type 2 diabetes (T2D), however, a number of patients discontinue...
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Safety of Combined Statin and Fibrate Therapy: Risks of Liver Injury and Acute Kidney Injury in a Cohort Study from the Shizuoka Kokuho Database
IntroductionStatins and fibrates are important means of preventing cardiovascular diseases, particularly when administered in combination as part of...
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Early Management of Blood Lipid Levels with Non-Statin Lipid-Lowering Drugs in Acute Coronary Syndrome: A Mini Review
Acute coronary syndrome (ACS) remains a major cause of morbidity and mortality, despite many improvements in its prevention and management. Lipid...
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The effect of a multi-component behavior change technique intervention on medication adherence among individuals on primary prevention statin therapy: a dose-finding protocol
BackgroundIn the USA, the primary cause of death and morbidity continues to be cardiovascular disease (CVD). Numerous trials have shown that statin...
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Factors Associated with Discontinuation of Statin Therapy in Patients with Lymphoma Aged 80 Years and Older: A Retrospective Single-Institute Study
BackgroundThere is little evidence to support or negate the benefits of statin therapy for primary prevention of cardiovascular disease (CVD) in...
