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Utilization of spontaneous breathing trial, objective cough test, and diaphragmatic ultrasound results to predict extubation success: COBRE-US trial
BackgroundThe results of clinical and weaning readiness tests and the spontaneous breathing trial (SBT) are used to predict the success of the...
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Combined cardiac, lung, and diaphragm ultrasound for predicting weaning failure during spontaneous breathing trial
BackgroundWeaning from invasive mechanical ventilation (MV) is a complex and challenging process that involves multiple pathophysiological...
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Diaphragmatic ultrasonography-based rapid shallow breathing index for predicting weaning outcome during a pressure support ventilation spontaneous breathing trial
BackgroundThe optimum timing to wean is crucial to avoid negative outcomes for mechanically ventilated patients. The rapid shallow breathing index...
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Comparative effectiveness of alternative spontaneous breathing trial techniques: a systematic review and network meta-analysis of randomized trials
BackgroundThe spontaneous breathing trial (SBT) technique that best balance successful extubation with the risk for reintubation is unknown. We...
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Electrical Impedance Tomography as a monitoring tool during weaning from mechanical ventilation: an observational study during the spontaneous breathing trial
BackgroundProlonged weaning from mechanical ventilation is associated with poor clinical outcome. Therefore, choosing the right moment for weaning...
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The diaphragmatic electrical activity during spontaneous breathing trial in patients with mechanical ventilation: physiological description and potential clinical utility
BackgroundsIncreased respiratory drive has been demonstrated to correlate with weaning failure, which could be quantified by electrical activity of...
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Diaphragmatic electromyography during a spontaneous breathing trial to predict extubation failure in preterm infants
BackgroundPremature attempts at extubation and prolonged episodes of ventilatory support in preterm infants have adverse outcomes. The aim of this...
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Spontaneous breathing trial with pressure support on positive end-expiratory pressure and extensive use of non-invasive ventilation versus T-piece in difficult-to-wean patients from mechanical ventilation: a randomized controlled trial
BackgroundThe aim of this study is to assess whether a strategy combining spontaneous breathing trial (SBT) with both pressure support (PS) and...
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Pressure support and positive end-expiratory pressure versus T-piece during spontaneous breathing trial in difficult weaning from mechanical ventilation: study protocol for the SBT-ICU study
BackgroundSpontaneous breathing trials are performed in critically ill intubated patients in order to assess readiness to be weaned from mechanical...
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The influence of chorioamnionitis on respiratory drive and spontaneous breathing of premature infants at birth: a narrative review
Most very premature infants breathe at birth but require respiratory support in order to stimulate and support their breathing. A significant...
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Accuracy of the spontaneous breathing trial using a combined CPAP + PSV model to predict extubation outcomes in very preterm infants
BackgroundVery preterm infants often require mechanical ventilation. However, objective criteria to predict the outcomes of extubation in very...
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Effect of high-flow oxygen versus T-piece ventilation strategies during spontaneous breathing trials on weaning failure among patients receiving mechanical ventilation: a randomized controlled trial
BackgroundA spontaneous breathing trial (SBT) is used to determine whether patients are ready for extubation, but the best method for choosing the...
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Effect of spontaneous breathing trial on extubation in patients with acute exacerbation of chronic obstructive pulmonary disease under mechanical ventilation
ObjectiveTo evaluate how spontaneous breathing trial (SBT) affects successful extubation and prognosis in acute exacerbation of chronic obstructive...
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Routine administration of neostigmine after recovery of spontaneous breathing versus neuromuscular monitor-guided administration of neostigmine in pediatric patients: a parallel, randomized, controlled study
BackgroundNeostigmine used to reverse the muscle relaxants should be guided by neuromuscular monitoring, as the degree of spontaneous pre-reversal...
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Inspiratory effort impacts the accuracy of pulse pressure variations for fluid responsiveness prediction in mechanically ventilated patients with spontaneous breathing activity: a prospective cohort study
BackgroundPulse pressure variation (PPV) is unreliable in predicting fluid responsiveness (FR) in patients receiving mechanical ventilation with...
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Pendelluft in hypoxemic patients resuming spontaneous breathing: proportional modes versus pressure support ventilation
BackgroundInternal redistribution of gas, referred to as pendelluft, is a new potential mechanism of effort-dependent lung injury. Neurally-adjusted...
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Feasibility and safety of deep sedation with propofol and remifentanil in spontaneous breathing during endoscopic retrograde cholangiopancreatography: an observational prospective study
BackgroundEndoscopic retrograde cholangiopancreatography (ERCP) is an interventional procedure that requires deep sedation or general anaesthesia....
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Implementation of coordinated spontaneous awakening and breathing trials using telehealth-enabled, real-time audit and feedback for clinician adherence (TEACH): a type II hybrid effectiveness-implementation cluster-randomized trial
BackgroundIntensive care unit (ICU) patients on mechanical ventilation often require sedation and analgesia to improve comfort and decrease pain....
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Frequent tracheal suctioning is associated with extubation failure in patients with successful spontaneous breathing trial: a single-center retrospective cohort study
BackgroundExtubation failure, i.e., reintubation in ventilated patients, is a well-known risk factor for mortality and prolonged stay in the...
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Do Cerebral Cortex Perfusion, Oxygen Delivery, and Oxygen Saturation Responses Measured by Near-Infrared Spectroscopy Differ Between Patients Who Fail or Succeed in a Spontaneous Breathing Trial? A Prospective Observational Study
BackgroundAlterations in perfusion to the brain during the transition from mechanical ventilation (MV) to a spontaneous breathing trial (SBT) remain...
