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Rapid and Sustained Effect of Ixekizumab on Patient Global, Spinal Pain, Stiffness, and Fatigue in Chinese Patients with Radiographic Axial Spondyloarthritis
IntroductionIxekizumab, an interleukin 17A (IL-17A) inhibitor, has demonstrated rapid and sustained improvement in the signs and symptoms in patients...
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Patient perception of leg length after total hip arthroplasty does not correlate with sagittal lumbar spine stiffness, history of spinal pathology or fusion
PurposeAlthough spinal pathology or fusion can change patients’ posture and pelvic orientation, their correlation with perception of limb length...
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Proximal junctional failure after surgical instrumentation in adult spinal deformity: biomechanical assessment of proximal instrumentation stiffness
Study designAssessment of different proximal instrumentation stiffness features to minimize the mechanical proximal junctional failure-related risks...
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Spasticity and Muscle Stiffness Restoring Form and Function
This book aids the practitioner in understanding the difference between spasticity and muscle stiffness, weighing old and new treatment options, and...
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Maximizing mechanical advantage: surgical technique increases stiffness in spinal instrumentation
PurposeWhile there has been a great improvement in the treatment of adolescent idiopathic scoliosis, sagittal deformity correction has remained...
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Ixekizumab improves spinal pain, function, fatigue, stiffness, and sleep in radiographic axial Spondyloarthritis: COAST-V/W 52-week results
BackgroundThis analysis assessed improvements in patients with radiographic axial spondyloarthritis (r-axSpA) treated with ixekizumab in the...
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A consensus approach toward the standardization of spinal stiffness measurement using a loaded rolling wheel device: results of a Delphi study
BackgroundSpinal stiffness assessment has the potential to become an important clinical measure. Various spinal stiffness-testing devices are...
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Operative strategies for ankylosing spondylitis-related thoracolumbar kyphosis: focus on the cervical stiffness, coronal imbalance and hip involvement
BackgroundCervical stiffness, coronal imbalance and limited hip movement all play crucial roles in designing the corrective surgery for ankylosing...
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Stiffness and axial pain are associated with the progression of calcification in a mouse model of diffuse idiopathic skeletal hyperostosis
BackgroundDiffuse idiopathic skeletal hyperostosis (DISH) is characterized by progressive calcification of spinal tissues; however, the impact of...
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Changes of trunk muscle stiffness in individuals with low back pain: a systematic review with meta-analysis
BackgroundLow back pain (LBP) is one of the most common musculoskeletal conditions. People with LBP often display changes of neuromuscular control...
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Time to improvement of pain, morning stiffness, fatigue, and disease activity in patients with ankylosing spondylitis treated with tofacitinib: a post hoc analysis
BackgroundTofacitinib is an oral Janus kinase inhibitor for treatment of ankylosing spondylitis (AS). Time to improvement in core domains of AS was...
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Dysfunctional paraspinal muscles in adult spinal deformity patients lead to increased spinal loading
PurposeDecreased spinal extensor muscle strength in adult spinal deformity (ASD) patients is well-known but poorly understood; thus, this study aimed...
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Pediatric spinal instrumentation
This article reviews the evolution of spinal instrumentation in the pediatric age group, starting with the cervical spine and atlantoaxial area and...
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Evaluation of myotonometry for myotonia, muscle stiffness and elasticity in neuromuscular disorders
Neuromuscular disorders show extremely varied expressions of different symptoms and the involvement of muscles. Non-invasively, myotonia and muscle...
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Changes in pain sensitivity and spinal stiffness in relation to responder status following spinal manipulative therapy in chronic low Back pain: a secondary explorative analysis of a randomized trial
BackgroundIn a prior randomized trial, we demonstrated that participants receiving spinal manipulative therapy at a pain-sensitive segment instead of...
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The bench-top accuracy of the VerteTrack spinal stiffness assessment device
BackgroundThe assessment of spinal stiffness by manual palpation in clinical settings has demonstrated both poor accuracy and reliability. More...
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Design and 3D printing of novel titanium spine rods with lower flexural modulus and stiffness profile with optimised imaging compatibility
PurposeTo manufacture and test 3D printed novel design titanium spine rods with lower flexural modulus and stiffness compared to standard solid...
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Fixation-induced surgical segment’s high stiffness and the damage of posterior structures together trigger a higher risk of adjacent segment disease in patients with lumbar interbody fusion operations
BackgroundAdjacent segment disease (ASD) is a commonly reported complication after lumbar interbody fusion (LIF); changes in the mechanical...
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Pediatric spinal cord diffuse midline glioma with H3 K27M-alteration with leptomeningeal dissemination: a rare case with intracranial hypertension onset and no spinal cord-related symptom
PurposeSpinal cord diffuse midline glioma (DMG) with H3 K27-alteration is a group of spinal cord high-grade glioma with poor outcome. We present a...
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The Role of Orthoses in Chronic Axial Spinal Conditions
Purpose of ReviewBracing represents a prevalent conservative, non-surgical approach used in the management of chronic spinal conditions such as...