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LC–MS metabolomics analysis of serum metabolites during neoadjuvant chemoradiotherapy in locally advanced rectal cancer
BackgroundThis study aimed to investigate the serum metabolite profiles during neoadjuvant chemoradiotherapy (NCRT) in locally advanced rectal cancer...
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Effects of sevoflurane anesthesia and abdominal surgery on the systemic metabolome: a prospective observational study
BackgroundMetabolic status can be impacted by general anesthesia and surgery. However, the exact effects of general anesthesia and surgery on...
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Association of 1-deoxy-sphingolipids with steatosis but not steatohepatitis nor fibrosis in non-alcoholic fatty liver disease
BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most important cause of chronic liver disease in the western world. Steatosis can be...
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Metabolomic profiling of upper GI malignancies in blood and tissue: a systematic review and meta-analysis
ObjectiveTo conduct a systematic review and meta-analysis of case–control and cohort human studies evaluating metabolite markers identified using...
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Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic dermatitis and psoriasis are common chronic inflammatory diseases of high incidence that share some clinical features, including symptoms of...
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Perinatal origins of chronic lung disease: mechanisms–prevention–therapy—sphingolipid metabolism and the genetic and perinatal origins of childhood asthma
Childhood asthma derives from complex host-environment interactions occurring in the perinatal and infant period, a critical time for lung...
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Phase I trial of intravenous fenretinide (4-HPR) plus safingol in advanced malignancies
PurposeFenretinide (4-HPR) is a synthetic retinoid that induces cytotoxicity through dihydroceramide production. Safingol, a stereochemical-variant...
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From Bacteria to Host: Deciphering the Impact of Sphingolipid Metabolism on Food Allergic Reactions
Purpose of ReviewAllergic diseases have become a burden in industrialized societies. Among children, food allergy (FA) constitutes a major impairment...
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Placental Production of Eicosanoids and Sphingolipids in Women Who Developed Preeclampsia on Low-Dose Aspirin
Low-dose aspirin, which selectively inhibits thromboxane synthesis, is now standard of care for the prevention of preeclampsia in at risk women, but...
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A feasibility study of metabolic phenoty** of dried blood spot specimens in rural Chinese women exposed to household air pollution
BackgroundExposure–response studies and policy evaluations of household air pollution (HAP) are limited by current methods of exposure assessment...
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Integrative network fusion-based multi-omics study for biomarker identification and patient classification of rheumatoid arthritis
BackgroundCold-dampness Syndrome (RA-Cold) and Hot-dampness Syndrome (RA-Hot) are two distinct groups of rheumatoid arthritis (RA) patients with...
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Metabolomics analysis of serum and urine in type 1 diabetes patients with different time in range derived from continuous glucose monitoring
BackgroundTime in range (TIR), as an important glycemic variability (GV) index, is clearly associated with disease complications in type 1 diabetes...
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Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study
Methamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms...
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Unveiling the metabolic landscape of pulmonary hypertension: insights from metabolomics
Pulmonary hypertension (PH) is regarded as cardiovascular disease with an extremely poor prognosis, primarily due to irreversible vascular...
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Current advances in noninvasive methods for the diagnosis of oral squamous cell carcinoma: a review
Oral squamous cell carcinoma (OSCC), one of the most common types of cancers worldwide, is diagnosed mainly through tissue biopsy. However, owing to...
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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection
ObjectiveHuman adenovirus (HAdV) infection is common and can develop to serious conditions with high mortality, yet the mechanism of HAdV infection...
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Untargeted metabolomic analysis of ischemic injury in human umbilical vein endothelial cells reveals the involvement of arginine metabolism
ObjectiveIn this study, differentially expressed metabolites of vascular endothelial cells were examined to further understand the metabolic...
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Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury
BackgroundAcute lung injury (ALI) is a severe inflammatory disease, underscoring the urgent need for novel treatments. Nauclea officinalis Pierre ex ...
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Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS- CoV-2 infectivity
Recently, COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, caused > 6 million deaths. Symptoms...
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Metabolomic insights into pulmonary fibrosis: a mendelian randomization study
BackgroundThis study leverages a two-sample Mendelian Randomization (MR) approach to explore the causal relationships between 1,400 metabolites and...
