Search
Search Results
-
Sperm chromatin accessibility’s involvement in the intergenerational effects of stress hormone receptor activation
Dexamethasone is a stress hormone receptor agonist used widely in clinics. We and others previously showed that paternal administration of...
-
Effects of alcohol use on sperm chromatin structure, a retrospective analysis
BackgroundThe evaluation of the infertile couple is often complex as multiple factors in both the male and female can contribute, including social...
-
Sperm chromatin structure assay (SCSA®) and flow cytometry-assisted TUNEL assay provide a concordant assessment of sperm DNA fragmentation as a function of age in a large cohort of approximately 10,000 patients
BackgroundSperm DNA integrity is increasingly seen as a critical characteristic determining reproductive success, both in natural reproduction and in...
-
In cases with raised sperm DNA fragmentation, can sperm selection by magnetic-activated cell sorting or testicular sperm aspiration help improve reproductive outcomes?
PurposeTo evaluate the efficacy of magnetic-activated cell sorting (MACS) or testicular sperm aspiration (TESA) to improve reproductive outcomes in...
-
The influence of paternal overweight on sperm chromatin integrity, fertilization rate and pregnancy outcome among males attending fertility clinic for IVF/ICSI treatment
BackgroundLow and middle-income countries are facing a rapid increase in obesity and overweight burden, particularly in urban settings. Being...
-
Cannabidiol impairs sperm quality and function in adult mice
BackgroundConsidering the growing therapeutic use of cannabidiol as well as the presence of cannabinoid receptors in sperm and its possible genotoxic...
-
The effect of zinc supplementation on improving sperm parameters in infertile diabetic men
Background and aimsDiabetes mellitus (DM) may have different adverse effects on the male reproductive system. Zinc (Zn) is one of the necessary...
-
Evaluation of in vitro effects of platelet rich plasma on cadmium chloride–treated rat sperm
Cadmium is a heavy metal with wide industrial applications. Humans are exposed to cadmium through different ways. Cadmium demonstrates a low...
-
Clinical Utility of Sperm Function Tests in Predicting Male Fertility: A Systematic Review
Routine semen analysis provides considerable information regarding sperm parameters; however, it is not solely adequate to predict male fertility...
-
Effects of adverse semen parameters on total oxidation status and DNA/chromatin integrity
BackgroundInfertility is a major health problem that affects 7% of the men’s population. Oxidative stress (OS) plays a significant role in the...
-
Methylation Status of cAMP-responsive Element Modulator (CREM) Gene in Infertile Men and Its Association with Sperm Parameters
The methylation pattern of non-imprinting genes was little studied, although it is widely known that the abnormal methylation levels of imprinting...
-
Effect of season on the dynamics of cat sperm DNA fragmentation
BackgroundFeline species undergo reproductive seasonality; thus, sperm characteristics, such as DNA integrity, can be affected by the photoperiod....
-
Male obesity is associated with sperm telomere shortening and aberrant mRNA expression of autophagy-related genes
BackgroundObesity is regarded a global public health crisis. It has been implicated in a variety of health problems, but when it comes to male...
-
External quality assessment scheme for sperm DNA fragmentation: a pilot study in China
BackgroundThe aim of this article is to establish an external quality assessment (EQA) scheme for sperm Deoxyribonucleic acid (DNA) fragmentation...
-
Live motile sperm sorting device for enhanced sperm-fertilization competency: comparative analysis with density-gradient centrifugation and microfluidic sperm sorting
PurposeA live motile sperm sorting device (LensHooke ® CA0) developed to prevent the deleterious effects of centrifugation was evaluated...
-
Micronutrient supplements as antioxidants in improving sperm quality and reducing DNA fragmentation
BackgroundSpermatogenesis and sperm quality may be negatively impacted by an increase in reactive oxygen species. This study investigates the...
-
Label-Free Evaluation of Chromatin Condensation in Human Normal Morphology Sperm Using Raman Spectroscopy
Chromatin condensation is one of the main factors essential for sperm function. Evaluation of chromatin condensation by current methods render the...
-
Sperm chromosomal abnormalities in infertile men with failed intracytoplasmic sperm injection (ICSI)
BackgroundMale infertility is a major health problem with multi-factorial etiology. Intracytoplasmic sperm injection (ICSI) has revolutionized the...
-
Advanced Paternal Age Affects the Sperm DNA Fragmentation Index and May Lead to Lower Good-quality Blastocysts
Several studies show reductions in some seminal parameters in aged men and describe them as a consequence of many age-dependent changes in male...
-
Relationship between dietary glycemic index and glycemic load and sperm-quality parameters in Iranian men: a cross-sectional study
BackgroundInfertility is a major clinical problem with psychological, financial and medical costs. Male infertility has recently been linked to 50%...