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Role of Sodium and Sodium Restriction in Heart Failure
Purpose of ReviewSodium plays an essential role in the regulation of extracellular volume. The current review discusses the physiologic handling of...
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Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy
Epilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges of the brain and a predisposition...
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l-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels
BackgroundWe previously reported that, among all the naturally occurring amino acids, l -valine is the most powerful luminal stimulator of...
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Emerging roles of mechanosensitive ion channels in acute lung injury/acute respiratory distress syndrome
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating respiratory disorder with high rates of mortality and morbidity,...
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Sodium Homeostasis and Hypertension
Purpose of ReviewThis review aims to summarize and discuss the relationship between sodium homeostasis and hypertension, including emerging concepts...
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High-throughput screening of transient receptor potential (TRP) channels in pterygium
PurposePterygium is a hyaline degenerative disease of the conjunctiva characterized by the progression of fibrovascular connective tissue from the...
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Erratum to: Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?
The article “Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?”, written by Zhi-mei LI, Li-xia CHEN, Hua LI, was...
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Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients
BackgroundMany antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes...
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Effect of low sodium and high potassium diet on lowering blood pressure and cardiovascular events
Incorporating aggressive lifestyle modifications along with antihypertensive medication therapy is a crucial treatment strategy to enhance the...
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Silybin induces endothelium-dependent vasodilation via TRPV4 channels in mouse mesenteric arteries
Silybin is a flavonolignan extracted from the seeds of Silybum marianum that has been used as a dietary supplement for treating hepatic diseases and...
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The salt sensitivity of Drd4-null mice is associated with the upregulations of sodium transporters in kidneys
To explore the mechanism of the hypertension in dopamine receptor-4 ( Drd4 ) null mice, we determined the salt sensitivity and renal sodium transport...
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Aquaporin water channels: roles beyond renal water handling
Aquaporin (AQP) water channels are pivotal to renal water handling and therefore in the regulation of body water homeostasis. However, beyond the...
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A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function
BackgroundPurified cannabidiol (CBD), a non-psychoactive phytocannabinoid, has gained regulatory approval to treat intractable childhood epilepsies....
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Emerging Medications and Strategies in Acute Pain Management: Evolving Role of Novel Sodium and Calcium Channel Blockers, Peptide-Based Pharmacologic Drugs, and Non-Medicinal Methods
Purpose of ReviewThe present investigation evaluated integration of novel medication technology to enhance treatment options, while improving patient...
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Exploitation of ATP-sensitive potassium ion (KATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK/AP-1 signalling
Persistent infection with high-risk human papillomaviruses (HPVs) is the causal factor in multiple human malignancies, including >99% of cervical...
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23Na MRI: inter-reader reproducibility of normal fibroglandular sodium concentration measurements at 3 T
BackgroundTo study the reproducibility of 23 Na magnetic resonance imaging (MRI) measurements from breast tissue in healthy volunteers.
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Mechanosensitive Piezo channels mediate the physiological and pathophysiological changes in the respiratory system
Mechanosensitive Piezo ion channels were first reported in 2010 in a mouse neuroblastoma cell line, opening up a new field for studying the...
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Persistent brain exposure to high sodium induces stroke onset by upregulation of cerebral microbleeds and oxidative stress in hypertensive rats
High salt intake induces hypertension and enhances stroke onset. However, whether an increase in brain sodium exposure itself is harmful and has poor...
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Activation of Kv7 channels normalizes hyperactivity of the VTA-NAcLat circuit and attenuates methamphetamine-induced conditioned place preference and sensitization in mice
The brain circuit projecting from the ventral tegmental area (VTA) to the nucleus accumbens lateral shell (NAcLat) has a key role in methamphetamine...
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Current Evidence Surrounding the Use of Sodium Bicarbonate in the Critically Ill Patient
Purpose of ReviewPatients requiring admission to the intensive care unit frequently develop severe metabolic acidosis. Severe and prolonged acidosis...