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Small molecule metabolites: discovery of biomarkers and therapeutic targets
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of...
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Efficacy and safety study of targeted small-molecule drugs in the treatment of systemic lupus erythematosus
BackgroundTargeted small-molecule drugs in the treatment of systemic lupus erythematosus (SLE) have attracted increasing attention from clinical...
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Small molecule inhibitors targeting m6A regulators
As the most common form of epigenetic regulation by RNA, N 6 methyladenosine (m 6 A) modification is closely involved in physiological processes, such...
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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic agents that target severe acute respiratory...
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Small molecule inhibitors for cancer metabolism: promising prospects to be explored
BackgroundAbnormal metabolism is the main hallmark of cancer, and cancer metabolism plays an important role in tumorigenesis, metastasis, and drug...
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Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy
Non-coding RNAs (ncRNAs) have been defined as a class of RNA molecules transcribed from the genome but not encoding proteins, such as microRNAs, long...
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The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling
Glioma is the most prevalent brain tumor, presenting with limited treatment options, while patients with malignant glioma and glioblastoma (GBM) have...
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Update on Small Molecule Targeted Therapies for Acute Myeloid Leukemia
The search for effective therapies for the highly heterogenous disease acute myeloid leukemia (AML) has remained elusive. While cytotoxic therapies...
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Chemical screening identifies novel small molecule activators of natural killer cell cytotoxicity against cancer cells
Natural killer (NK) cells are cytotoxic lymphocytes that play a major role in the innate immune system. NK cells exhibit potent cytotoxic activity...
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Small-molecule amines: a big role in the regulation of bone homeostasis
Numerous small-molecule amines (SMAs) play critical roles in maintaining bone homeostasis and promoting bone regeneration regardless of whether they...
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2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide + (NAD + )-dependent deacetylase located in the mitochondria that may...
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Discovery of small molecule degraders for modulating cell cycle
The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is...
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Identification of small molecule inhibitors against Lin28/let-7 to suppress tumor progression and its alleviation role in LIN28-dependent glucose metabolism
The reciprocal suppression of an RNA-binding protein LIN28 (human abnormal cell lineage 28) and miRNA Let-7 (Lethal 7) is considered to have a prime...
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Role of Small Molecule Ligands in IgE-Mediated Allergy
Purpose of ReviewA significant fraction of allergens bind small molecular ligands, and many of these compounds are classified as lipids. However, in...
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A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer
Protein neddylation is catalyzed by a neddylation activating enzyme (NAE, E1), an E2 conjugating enzyme, and an E3 ligase. In various types of human...
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Small molecule inhibitors of the VEGF and tyrosine kinase for the treatment of cervical cancer
Cervical cancer accounts for most deaths due to cancer in women, majorly in develo** nations. The culprit behind this disease is the human...
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A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming
Treatment of patients with triple-negative breast cancer (TNBC) has been challenging due to the absence of well-defined molecular targets and the...
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Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth
NEMO/IKKβ complex is a central regulator of NF-κB signaling pathway, its dissociation has been considered to be an attractive therapeutic target....
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The Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, an Oral Small Molecule Factor XIa Inhibitor, in Healthy Chinese Volunteers
Background and ObjectiveThere is an unmet need for a safer anticoagulant since bleeding remains a concern with currently approved anticoagulants....
