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Small interfering RNA (siRNA) as a potential gene silencing strategy for diabetes and associated complications: challenges and future perspectives
ObjectiveThis article critically reviews the recent search on the use of Small Interfering RNA (siRNA) in the process of gene regulation that has...
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Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection
This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient...
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Updates in Small Interfering RNA for the Treatment of Dyslipidemias
Purpose of ReviewAtherosclerotic cardiovascular disease (ASCVD) is still the leading cause of death worldwide. Despite excellent pharmacological...
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RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization
BackgroundDNA methyltransferase 1 (DNMT1) exerts imperative functions in neuropathic pain (NP). This study explored the action of RNA...
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Immunoinformatic and molecular docking approaches: siRNA prediction to silence cell surface binding protein of monkeypox virus
BackgroundMonkeypox virus (MPV), an endemic pathogen in Africa, shares clinical similarities with smallpox. Recent reports indicate a concerning...
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Hitting Epstein Barr virus where it hurts: computational methods exploration for siRNA therapy in alleviating Epstein Barr virus-induced multiple sclerosis
Multiple sclerosis (MS), an intricate neurological disorder, continues to challenge our understanding of the pivotal interplay between the immune...
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siRNA and Ovarian Cancer
RNA interference (RNAi) is an emerging field of genetic intervention of the new millennium for incurable disease conditions where conventional...
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A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA
BackgroundCurrently, standard treatments for chronic hepatitis B such as nucleos(t)ide analogs (NAs), effectively reduce hepatitis B virus (HBV)...
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Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway
The aberrant expression of the long non-coding RNA (lncRNA) Small Nucleolar RNA Host Gene 29 (SNHG29) has been associated with various human cancers....
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The Role of Small Interfering RNAs in Hepatocellular Carcinoma
BackgroundHepatocellular carcinoma (HCC), a primary liver cancer with high mortality, is the most common malignant tumor in the world. Currently, the...
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An ncRNA transcriptomics-based approach to design siRNA molecules against SARS-CoV-2 double membrane vesicle formation and accessory genes
BackgroundThe corona virus SARS-CoV-2 is the causative agent of recent most global pandemic. Its genome encodes various proteins categorized as...
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siRNA and targeted delivery systems in breast cancer therapy
Recently, nucleic acid drugs have been considered as promising candidates in treatment of various diseases, especially cancer. Because of develo**...
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Characterization of PDL1 enhanced siRNA/albumin liposome for effective therapeutic function in lung cancer
PurposeThe applications of liposomes are limited due to poor structural stability and short drug circulation time. This study aims to build an...
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In silico prediction of siRNA to silence the SARS-CoV-2 omicron variant targeting BA.4, BA.5, BQ.1, BQ1.1. and XBB: an alternative to traditional therapeutics
BackgroundAfter the first infection in December 2019, the mutating strains of SARS-CoV2 have already affected a lot of healthy people around the...
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Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B
Small interfering RNA (siRNA) constitutes a promising therapeutic modality supporting the potential functional cure of hepatitis B. A novel ionizable...
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Engineering approaches for RNA-based and cell-based osteoarthritis therapies
Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the quality of life of affected individuals. The underlying...
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Preparation, characterization, and in-vitro cytotoxicity of nanoliposomes loaded with anti-tubercular drugs and TGF-β1 siRNA for improving spinal tuberculosis therapy
BackgroundTuberculosis (TB) represents a bacterial infection affecting many individuals each year and potentially leading to death. Overexpression of...
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Nephroblastoma-specific dysregulated gene SNHG15 with prognostic significance: scRNA-Seq with bulk RNA-Seq data and experimental validation
Wilms tumor (WT) is the most common malignancy of the genitourinary system in children. Currently, the Integration of single-cell RNA sequencing...
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Targeting Lipoprotein(a): Can RNA Therapeutics Provide the Next Step in the Prevention of Cardiovascular Disease?
Numerous genetic and epidemiologic studies have demonstrated an association between elevated levels of lipoprotein(a) (Lp[a]) and cardiovascular...
