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Single posterior approach for circumferential debridement and anterior reconstruction using fibular allograft in patients with skipped multifocal spinal tuberculosis
BackgroundSkipped multifocal spinal tuberculosis (TB) is an atypical presentation of spinal TB. Surgical treatment for these unusual cases remains a...
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Hypoglycaemia frequency and physiological response after double or triple doses of once-weekly insulin icodec vs once-daily insulin glargine U100 in type 2 diabetes: a randomised crossover trial
Aims/hypothesisThis study compared the frequency of hypoglycaemia, time to hypoglycaemia and recovery from hypoglycaemia after double or triple doses...
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Understanding suboptimal insulin use in type 1 and 2 diabetes: a cross-sectional survey of healthcare providers who treat people with diabetes
BackgroundThe purpose of this study was to understand the healthcare provider (HCP) perspective on the extent of suboptimal insulin dosing in people...
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Efficacy of a New Protocol of Premixed 70/30 Human Insulin in Haitian Youth with Diabetes
IntroductionControlling insulin-treated diabetes is challenging in low-resource settings where only Neutral Protamine Hagedorn (NPH), regular (R) and...
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Efficacy of standardizing fibrinolytic therapy for parapneumonic effusion
BackgroundWhile chest tube placement with pleural fibrinolytic medication is the established treatment of pediatric empyema, treatment failure is...
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Socio-behavioral factors related to PrEP non-adherence among gay male PrEP users living in California and New York: A behavioral theory informed approach
One effective preventative measure to reduce the number of new HIV infections is through the uptake of daily oral HIV pre-exposure prophylaxis...
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Contribution of cost to treatment nonadherence in the US breast cancer survivors: a population-based analysis
IntroductionBreast cancer survivors are often prescribed medications for at least 5 years to reduce recurrence risk, yet some forego this treatment...
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Cost-related medication nonadherence in adults with COPD in the United States 2013–2020
BackgroundCost-related medication nonadherence (CRN) is associated with poor prognosis among patients with chronic obstructive pulmonary disease...
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Personality traits favourable for non-adherence to treatment in patients with chronic myeloid leukaemia: role of type A and D personality
BackgroundThe introduction of BCR-ABL tyrosine kinase inhibitors (TKIs) to chronic myeloid leukemia (CML) therapy has revolutionized the treatment of...
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The impact of the COVID-19 pandemic on Fabry Disease Patients: an examination of Mood Status, Therapy Adherence, and COVID-19 infection
BackgroundFabry disease (FD) is a rare metabolic disorder, in which a lifelong enzyme replacement therapy (ERT) constitutes the cornerstone of...
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INTERCEPT H3: a multicenter phase I peptide vaccine trial for the treatment of H3-mutated diffuse midline gliomas
IntroductionDiffuse midline gliomas (DMG) are universally lethal central nervous system tumors that carry almost unanimously the clonal driver...
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MIB Guides: Preclinical Radiopharmaceutical Dosimetry
Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating...
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Profiling of antimicrobial dispensing practices in accredited drug dispensing outlets in Tanzania: a mixed-method cross-sectional study focusing on pediatric patients
BackgroundThe emergency of antimicrobial resistance due to irrational antimicrobial use has put public health under threat. Accredited Drug...
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Phase I study of the VEGF/Ang-2 inhibitor BI 836880 alone or combined with the anti-programmed cell death protein-1 antibody ezabenlimab in Japanese patients with advanced solid tumors
PurposeThis two-part, open-label, non-randomized dose-escalation study aimed to define the maximum tolerated dose (MTD) of BI 836880 (humanized...
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The psychological state and changes in the routine of the patients with rheumatic diseases during the coronavirus disease (COVID-19) outbreak in Turkey: a web-based cross-sectional survey
We hypothesized that patients with rheumatic diseases (RD) would have increased psychological distress during the COVID-19 outbreak; therefore,...