Search
Search Results
-
Immunophenoty** with (phospho)protein profiling and fluorescent cell barcoding for single-cell signaling analysis and biomarker discovery
The microenvironment of hematologic cancers contributes to tumor cell survival and proliferation, as well as treatment resistance. Understanding...
-
Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
Advances in chimeric antigen receptor (CAR)-T cell therapy have significantly improved clinical outcomes of patients with relapsed or refractory...
-
Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice
Aims/hypothesisIslets have complex heterogeneity and subpopulations. Cell surface markers representing alpha, beta and delta cell subpopulations are...
-
Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution
T follicular helper (T FH ) cell lymphomas (TFHLs) are characterized by T FH -like properties and accompanied by substantial immune-cell infiltration...
-
Profiling joint tissues at single-cell resolution: advances and insights
Advances in the profiling of human joint tissues at single-cell resolution have provided unique insights into the organization and function of these...
-
Glioblastoma heterogeneity at single cell resolution
Glioblastoma (GBM) is one of the deadliest types of cancer and highly refractory to chemoradiation and immunotherapy. One of the main reasons for...
-
Single-cell sequencing of tumour infiltrating T cells efficiently identifies tumour-specific T cell receptors based on the T cell activation score
Adoptively transferred T cell receptor-engineered T cells are a promising cancer treatment strategy, and the identification of tumour-specific TCRs...
-
Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma
BackgroundAsthma is a heterogeneous disease characterized by airway inflammation and remodeling, whose pathogenetic complexity was associated with...
-
Understanding Spondyloarthritis Pathogenesis: The Promise of Single-Cell Profiling
Purpose of ReviewSingle-cell profiling, either in suspension or within the tissue context, is a rapidly evolving field. The purpose of this review is...
-
Deciphering Müller cell heterogeneity signatures in diabetic retinopathy across species: an integrative single-cell analysis
Diabetic retinopathy (DR), a leading cause of visual impairment, demands a profound comprehension of its cellular mechanisms to formulate effective...
-
Predicting drug response from single-cell expression profiles of tumours
BackgroundIntra-tumour heterogeneity (ITH) presents a significant obstacle in formulating effective treatment strategies in clinical practice....
-
Practical Compass of Single-Cell RNA-Seq Analysis
Purpose of ReviewThis review paper provides step-by-step instructions on the fundamental process, from handling fastq datasets to illustrating plots...
-
Heterogeneity and tumoral origin of medulloblastoma in the single-cell era
Medulloblastoma is one of the most common malignant pediatric brain tumors derived from posterior fossa. The current treatment includes maximal safe...
-
Single-cell transcriptome analysis upon ECM-remodeling meningioma cells
Meningiomas are the most common tumours that primarily arise in the central nervous system, but their intratumoural heterogeneity has not yet been...
-
CRISPR screening in hematology research: from bulk to single-cell level
The CRISPR genome editing technology has revolutionized the way gene function is studied. Genome editing can be achieved in single genes or for...
-
The single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with...
-
Exploring natural killer cell-related biomarkers in multiple myeloma: a novel nature killer cell-related model predicting prognosis and immunotherapy response using single-cell study
BackgroundNatural killer cells (NKs) may be involved in multiple myeloma (MM) progression. The present study elucidated the correlation between NKs...
-
Application of Single-Cell Genomics in Cardiovascular Research
Cardiovascular diseases (CVDs) are the leading cause of death in the global world. The emergence of single-cell technologies has greatly facilitated...
-
Deciphering tumor-infiltrating dendritic cells in the single-cell era
Dendritic cells (DCs) serve as a pivotal link connecting innate and adaptive immunity by processing tumor-derived antigens and activating T cells....
-
Charting the cellular landscape of pulmonary arterial hypertension through single-cell omics
This review examines how single-cell omics technologies, particularly single-cell RNA sequencing (scRNAseq), enhance our understanding of pulmonary...
