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The role of endotoxin in septic shock
Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7...
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Echocardiographic characteristics in neonates with septic shock
Clinical parameters used for hemodynamic assessment and titration of vasopressor therapy in neonates with septic shock have several limitations....
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Impaired angiotensin II signaling in septic shock
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that...
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A model of porcine polymicrobial septic shock
BackgroundSepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is...
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Whole blood transcriptomics identifies subclasses of pediatric septic shock
BackgroundSepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted investigators to...
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Administration of methylene blue in septic shock: pros and cons
Septic shock typically requires the administration of vasopressors. Adrenergic agents remain the first choice, namely norepinephrine. However, their...
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Carbapenem is not always the best choice in the treatment of septic shock
BackgroundSeptic shock is a global public health burden. In addition to the improvement of the level of individual care, the improvement of the...
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Hemodynamic Management Strategies in Pediatric Septic Shock: Ten Concepts for the Bedside Practitioner
The three pathophysiologic contributors to septic shock include varying combinations of hypovolemia (relative > absolute), decreased vascular tone or...
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Evidence for a personalized early start of norepinephrine in septic shock
During septic shock, vasopressor infusion is usually started only after having corrected the hypovolaemic component of circulatory failure, even in...
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C-reactive protein and procalcitonin during course of sepsis and septic shock
ObjectiveThe study investigates the diagnostic and prognostic value of C-reactive protein (CRP) and procalcitonin (PCT) in patients with sepsis and...
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Thiamine administration in septic shock: a post hoc analysis of two randomized trials
BackgroundThis is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration...
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Association between prehospital ROX index with 30-day mortality among septic shock
PurposeRespiratory dysfunction is one of the most frequent symptoms observed during sepsis reflecting hypoxemia and/or acidosis that may be assessed...
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Severe mental illness and mortality in sepsis and septic shock: a systematic review and meta-analysis
BackgroundThere have been conflicting reports regarding the case-fatality outcomes associated with sepsis and septic shock in patients with severe...
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The value of IL-6, PCT, qSOFA, NEWS, and SIRS to predict septic shock after Percutaneous nephrolithotomy
BackgroundThere are numerous methods available for predicting sepsis following Percutaneous Nephrolithotomy. This study aims to compare the...
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Risk factors for PTSD symptoms following PICU admission for childhood septic shock
Objective
Paediatric intensive care unit (PICU) admission represents a traumatic event for many children. Follow-up studies have found post-traumatic...
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Diastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department
ObjectiveGiven the scarcity of studies analyzing the clinical predictors of pediatric septic cases that would progress to septic shock, this study...
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Lung ultrasound–guided fluid resuscitation in neonatal septic shock: A randomized controlled trial
This randomized controlled trial aimed to determine whether lung ultrasound–guided fluid resuscitation improves the clinical outcomes of neonates...
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Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23
BackgroundIn the last decades, several adjunctive treatments have been proposed to reduce mortality in septic shock patients. Unfortunately,...
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Septic shock due to Clostridium botulinum: a case report
BackgroundClostridium botulinum is an anaerobic, Gram-positive, rod-shaped bacterium that forms spores and the neurotoxin botulinum. It is best...
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Angiotensin 1–7 in an experimental septic shock model
BackgroundAlterations in the renin–angiotensin system have been implicated in the pathophysiology of septic shock. In particular, angiotensin 1–7...
