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Mirtazapine-induced neutropenic sepsis in an older person: a case report
BackgroundMirtazapine is a frequently prescribed psychotropic drug for depression in older age. It is considered safe and has a side-effect profile...
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Neutropenic ulcers in oncology: terminology, diagnosis, and management
Neutropenic ulcerations are characterized by mucosal ulcerations which occur in the presence of neutropenia, suggesting a direct link between...
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Risk Factors for Neutropenic Sepsis Related Mortality in Children Undergoing Allogenic Hematopoietic Stem Cell Transplantation
We aimed to analyze infections in children undergoing hematopoietic stem cell transplantation (HSCT) until engraftment. The spectrum and risk factors...
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Diagnostic accuracy of procalcitonin in adult non-neutropenic cancer patients with suspected infection: a systematic review and meta-analysis
BackgroundProcalcitonin (PCT) has garnered attention as a potential diagnostic biomarker for infection in cancer patients. We performed a systematic...
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Neutropenic enterocolitis-induced sepsis and disseminated intravascular coagulation after chemotherapy: a case report
BackgroundNeutropenic enterocolitis (NE) is a potentially life-threatening disease that primarily occurs in cancer patients treated with...
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Gastrointestinal Surgical Emergencies in the Neutropenic Immunocompromised Patient
Surgeons encounter neutropenic patients through elective or emergency consultation with increasing regularity. As medical management continues to...
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Towards personalized medicine: a sco** review of immunotherapy in sepsis
Despite significant progress in our understanding of the pathophysiology of sepsis and extensive clinical research, there are few proven therapies...
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Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization
High-dose cyclophosphamide (HD-Cy) (3 g/m 2 ) plus granulocyte colony-stimulating factor (G-CSF) is a very effective regimen for peripheral blood stem...
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Case reports of invasive mucormycosis associated neutropenic enterocolitis in leukemic children: diagnostic and treatment challenges and review of literature
BackgroundBacterial enterocolitis is one of the most common neutropenic fever complications during intensive chemotherapy. Despite aggressive...
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Vascular leak in sepsis: physiological basis and potential therapeutic advances
Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting...
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Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23
BackgroundIn the last decades, several adjunctive treatments have been proposed to reduce mortality in septic shock patients. Unfortunately,...
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How to use biomarkers of infection or sepsis at the bedside: guide to clinicians
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be...
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Sensitivity and specificity of monocyte distribution width (MDW) in detecting patients with infection and sepsis in patients on sepsis pathway in the emergency department
PurposeMonocyte distribution width (MDW) is a biomarker for the early identification of sepsis. We assessed its accuracy in patients presenting with...
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Sepsis mortality among patients with haematological malignancy admitted to intensive care 2000–2022: a binational cohort study
BackgroundSepsis occurs in 12–27% of patients with haematological malignancy within a year of diagnosis. Sepsis mortality has improved in non-cancer...
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Clinical and microbiological profiles in post-chemotherapy neutropenic fever in hematological malignancy: exploration of clinical phenotype patterns by two-step cluster analysis
BackgroundEpidemiology of infectious diseases causing febrile illness varies geographically with human attributes. Periodic institutional...
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Patient characteristics in sepsis-related deaths: prevalence of advanced frailty, comorbidity, and age in a Norwegian hospital trust
ObjectiveTo examine the prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths in an adult hospital population.
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Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression
Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice...
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The evolving value of older biomarkers in the clinical diagnosis of pediatric sepsis
AbstractSepsis remains the leading cause of childhood mortality worldwide. The evolving definition of pediatric sepsis is extrapolated from adult...
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Acute Abdominal Complications in Deeply Neutropenic Onco-Hematology Patients: A Retrospective Series of 105 Cases
BackgroundAcute abdominal complications (AAC) in patients with deep neutropenia (DN) is challenging to manage because of the expected influence of...
