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Pediatric Sepsis: New Strategies for Reducing Sepsis Related Mortality
Sepsis is one of the leading causes of morbidity and mortality in children. Timely recognition and management of sepsis with fluid resuscitation and...
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Sepsis mimics among presumed sepsis patients at intensive care admission: a retrospective observational study
BackgroundDiagnosing sepsis remains a challenge because of the lack of gold-standard diagnostics. Since there are no simple, broadly accepted...
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Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis
PurposeThere is evidence that cholinergic imbalance secondary to neuroinflammation plays a role in the pathophysiology of sepsis-associated...
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Respiratory tract viral infections associated sepsis in patients with underlying liver disease: Viral sepsis an entity to look forward!
BackgroundSepsis remains a global health burden associated with significant morbidity and mortality. Bacteria are known to be the predominant...
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Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines
Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal...
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Inflammation, sepsis severity and neurodevelopmental outcomes of late-onset sepsis in preterm neonates
BackgroundThe aim of this study was to investigate the association between inflammatory biomarkers (C-reactive protein (CRP), procalcitonin (PCT) and...
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Sepsis incidence, suspicion, prediction and mortality in emergency medical services: a cohort study related to the current international sepsis guideline
PurposeSepsis suspicion by Emergency Medical Services (EMS) is associated with improved patient outcomes. This study assessed sepsis incidence and...
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Leitliniengerechte Therapie der Sepsis
The time to administration of broad-spectrum antibiotics and (secondarily) to the initiation of hemodynamic stabilization are the most important...
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Characteristics and Risk Factors for Pediatric Sepsis
ObjectiveSepsis is considered a major cause of health loss in children and had high mortality and morbidity. Currently, there is no reliable model...
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Peripartum Sepsis
Purpose of ReviewMaternal sepsis is a leading cause of maternal mortality. The purpose of this review is to go in standard and nuanced care in its...
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Real-time machine learning-assisted sepsis alert enhances the timeliness of antibiotic administration and diagnostic accuracy in emergency department patients with sepsis: a cluster-randomized trial
Machine learning (ML) has been applied in sepsis recognition across different healthcare settings with outstanding diagnostic accuracy. However, the...
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Polymicrobial bloodstream infections per se do not increase mortality compared to monomicrobial bloodstream infections in sepsis patients: a Korean nationwide sepsis cohort study
BackgroundThere is limited information about the outcomes of polymicrobial bloodstream infections in patients with sepsis. We aimed to investigate...
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Most patients with an increased risk for sepsis-related morbidity or death do not recognize sepsis as a medical emergency: results of a survey study using case vignettes
BackgroundSepsis is a medical emergency with potentially life-threatening consequences. Patients play a crucial role in preventing and recognizing...
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Challenges of assessing the burden of sepsis
BackgroundSepsis is one of the most frequent causes of death worldwide, but the recording of population-based epidemiology is challenging, which is...
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Understanding health care pathways of patients with sepsis: protocol of a mixed-methods analysis of health care utilization, experiences, and needs of patients with and after sepsis
BackgroundSepsis is associated with about 20% of deaths worldwide. It often presents with non-specific initial symptoms, making its emergency...
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Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology
AbstractThe highest incidence of sepsis across all age groups occurs in neonates leading to substantial mortality and morbidity. Cardiovascular...
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Societal costs of sepsis in the Netherlands
BackgroundSepsis is a life-threatening syndrome characterized by acute loss of organ function due to infection. Sepsis survivors are at risk for...
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Biomarkers estimating baseline mortality risk for neonatal sepsis: nPERSEVERE: neonate-specific sepsis biomarker risk model
BackgroundPrognostic biomarker research neonatal sepsis is lacking. We assessed the utility of a validated pediatric prognostic tool called PERSEVERE...
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Persistent high sepsis-induced coagulopathy and sequential organ failure assessment scores can predict the 28-day mortality of patients with sepsis: A prospective study
BackgroundThe performance of the sepsis-induced coagulopathy (SIC) and sequential organ failure assessment (SOFA) scores in predicting the prognoses...
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Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis
BackgroundSepsis is defined as a life-threatening syndrome caused by an unbalanced host response to infection. The role of interleukin (IL)-36...
