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Comparison of diagnosis-based risk adjustment methods for episode-based costs to apply in efficiency measurement
BackgroundThe recent rising health spending intrigued efficiency and cost-based performance measures. However, mortality risk adjustment methods are...
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Early prediction of unfavorable evolution after a first clinical episode suggestive of multiple sclerosis: the EUMUS score
BackgroundPredicting disease progression in patients with the first clinical episode suggestive of multiple sclerosis (MS) is crucial for...
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Potential role between inflammatory cytokines and Tie-2 receptor levels and clinical symptoms in patients with first-episode schizophrenia
BackgroundSchizophrenia (SCZ) is associated with chronic low-grade inflammation, which may be involved in the underlying pathological mechanism of...
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Glucose dysregulation in antipsychotic-naive first-episode psychosis: in silico exploration of gene expression signatures
Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early dysglycemia, including insulin resistance and prediabetes. Metabolic...
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Role of DSM5 anxious distress specifier interview in acute manic episode: sociodemographic characteristics, clinical presentation and quality of life
BackgroundDSM 5 anxious distress specifier is one of the newly added specifiers for bipolar and related disorders. It may have impacts on the...
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Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy
Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been associated with cortico-striatal dysfunction. This work has...
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Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies
There is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major...
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A novel blood-based epigenetic biosignature in first-episode schizophrenia patients through automated machine learning
Schizophrenia (SCZ) is a chronic, severe, and complex psychiatric disorder that affects all aspects of personal functioning. While SCZ has a very...
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Policy Complexities in Financing First Episode Psychosis Services: Implementation Realities from a Home Rule State
Over the past decade, significant investments have been made in coordinated specialty care (CSC) models for first episode psychosis (FEP), with the...
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Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium
Using machine learning, we recently decomposed the neuroanatomical heterogeneity of established schizophrenia to discover two volumetric subgroups—a...
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The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine...
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Adaption and validation of the Rwandese version of the Young Mania Rating Scale to measure the severity of a manic or hypomanic episode
BackgroundBipolar Disorder is one of the most incapacitating diseases among young persons, leading to cognitive and functional impairment and raised...
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Comprehensive spatial distribution of patients with first-episode psychosis (FEP) and its relation to socio-economic factors
BackgroundThe functional-cognitive impact of first-episode psychosis (FEP) is extremely relevant and implies dysfunction from early life stages like...
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Macroscale EEG characteristics in antipsychotic-naïve patients with first-episode psychosis and healthy controls
Electroencephalography in patients with a first episode of psychosis (FEP) may contribute to the diagnosis and treatment response prediction....
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Provider Intentions to Implement Cannabis Use Intervention in First Episode Psychosis Treatment
Young adults with first episode psychosis use cannabis at high rates. In light of progressively tolerant attitudes toward cannabis, decreased...
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Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-naïve patients with major depressive disorder
BackgroundMajor depressive disorder (MDD) is a common psychiatric disorder worldwide. Psychotic depression has been reported to be frequently...
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The relationship between visual hallucinations, functioning, and suicidality over the course of illness: a 10-year follow-up study in first-episode psychosis
Visual hallucinations in psychosis are under-researched despite associations with increased illness severity, functional impairments, and suicidality...
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Brain structural correlates of recurrence following the first episode in patients with major depressive disorder
Former prospective studies showed that the occurrence of relapse in Major Depressive Disorder (MDD) is associated with volume loss in the insula,...
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Audiovisual temporal processing in adult patients with first-episode schizophrenia and high-functioning autism
Schizophrenia and autism spectrum disorder (ASD) are both neurodevelopmental disorders with altered sensory processing. Widened temporal binding...
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Identification of texture MRI brain abnormalities on first-episode psychosis and clinical high-risk subjects using explainable artificial intelligence
Structural MRI studies in first-episode psychosis and the clinical high-risk state have consistently shown volumetric abnormalities. Aim of the...
