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Comparison of the Effects of Intravenous Sedatives on Outcome in Adult Critically ill Patients: a Bayesian Network Analysis
BackgroundThis Bayesian network analysis was performed to assess the effects of different intravenous sedatives on outcomes in adult critically ill...
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Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials
Conventional gabaminergic sedatives such as benzodiazepines and propofol are commonly used in mechanically ventilated patients in the intensive care...
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Higher Cumulative Dose of Opioids and Other Sedatives are Associated with Extubation Failure in Norwood Patients
BackgroundThe primary purpose of this study is to evaluate the relationship between sedation usage and extubation failure, and to control for the...
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Frailty Risks of Prescription Analgesics and Sedatives across Frailty Models: the Health and Retirement Study
IntroductionLimited evidence for incident frailty risks associated with prescription analgesics and sedatives in older (≥ 65 years) community-living...
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Depression and ability to work after vestibular schwannoma surgery: a nationwide registry-based matched cohort study on antidepressants, sedatives, and sick leave
BackgroundIn patients with vestibular schwannomas (VS), tumor control is often achieved, and life expectancy is relatively good. The main risks of...
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Postoperative recovery among head and neck cancer patients receiving microvascular free flap surgery with implementing nurse-protocolized targeted sedation: relationship of use of sedatives and mechanical ventilation to length of ICU stay
PurposePatients receiving microvascular free flap surgery are usually admitted to a high-dependency adult intensive care unit (ICU). Research is...
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Barriers, facilitators and needs to deprescribe benzodiazepines and other sedatives in older adults: a mixed methods study of primary care provider perspectives
BackgroundBenzodiazepines and other sedative hypnotic drugs (BSHs) are frequently prescribed for sleep problems, but cause substantial adverse...
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An evaluation of dexmedetomidine in combination with midazolam in pediatric sedation: a systematic review and meta-analysis
BackgroundDexmedetomidine and midazolam are commonly used sedatives in children. We conducted a systematic review and meta-analysis to compare the...
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Consumption of psychotropic drugs in Croatia before and during the COVID-19 pandemic: a 10-year longitudinal study (2012–2021)
PurposeThis longitudinal study aimed to examine the trends in antipsychotics, antidepressants, anxiolytics, and hypnotics/sedatives consumption in...
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Opioid, sedative, preadmission medication and iatrogenic withdrawal risk in UK adult critically ill patients: a point prevalence study
BackgroundIatrogenic withdrawal syndrome, after exposure medication known to cause withdrawal is recognised, yet under described in adult intensive...
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Comparative analysis of dexmedetomidine, midazolam, and propofol impact on epilepsy-related mortality in the ICU: insights from the MIMIC-IV database
BackgroundDexmedetomidine (Dex), midazolam, and propofol are three distinct sedatives characterized by varying pharmacological properties. Previous...
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Depression, Suicidal Ideation, and Consumption of Psychotropic Drugs During Lockdown by COVID-19 According to Gender and Age
The objective was to analyze the relationship between depression and suicidal ideation and psychotropic drugs use during COVID-19 lockdown in adult...
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Long-term neurocognitive outcomes after pediatric intensive care: exploring the role of drug exposure
BackgroundConcerns exist regarding the impact of widely used clinical drugs on brain development. This study investigates long-term neurocognitive...
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Sleep disorders related to index and comorbid mental disorders and psychotropic drugs
PurposeMental disorders positively associate with sleep disorders. This study will explore the moderating influence of comorbid mental disorders and...
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Opioid use disorder in two samples of the Lebanese population: scale validation and correlation with sleep and mood disorders
BackgroundThe revised Opioid Risk Tool (ORT-OUD) is a brief, self-report scale designed to provide clinicians with a simple, validated method to...
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The role of perioperative sedative anesthetics in preventing postoperative delirium: a systematic review and network-meta analysis including 6679 patients
ObjectivePostoperative delirium is a common and debilitating complication that significantly affects patients and their families. The purpose of this...
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Use of dexmedetomidine in patients with sepsis: a systematic review and meta-analysis of randomized-controlled trials
BackgroundDexmedetomidine is widely used in patients with sepsis. However, its effect on septic patients remains controversial. The objective of this...
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Outpatient opioid prescribing by Alzheimer’s diagnosis among older adults with pain in United States
ObjectiveTo examine opioid prescribing practices for pain in older adults with and without Alzheimer’s Disease and Related Dementias (ADRD).
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Cerebrospinal fluid metabolic profiling reveals divergent modulation of pentose phosphate pathway by midazolam, propofol and dexmedetomidine in patients with subarachnoid hemorrhage: a cohort study
BackgroundAgitation is common in subarachnoid hemorrhage (SAH), and sedation with midazolam, propofol and dexmedetomidine is essential in agitation...
