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Multiple secondary outcome analyses: precise interpretation is important
Analysis of multiple secondary outcomes in a clinical trial leads to an increased probability of at least one false significant result among all...
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Secondary analyses of sex differences in attention improvements across three clinical trials of a digital therapeutic in children, adolescents, and adults with ADHD
BackgroundAttention-deficit/hyperactivity disorder (ADHD) remains underdiagnosed and undertreated in girls. Inattentive symptoms, often predominant...
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Aetiology and management options for secondary referred otalgia: a systematic review and meta-analyses
Objectives of reviewTo review the literature for the evidence base for the aetiology and management of referred otalgia, looking particularly at...
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Factor structure of the Oxford Shoulder Score: secondary analyses of the UK FROST and PROFHER trial populations
AimsFrozen shoulder and proximal humeral fracture can cause pain, stiffness and loss of function. The impact of these symptoms on patients can be...
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Are Dutch adults equally susceptible to nudging and pricing strategies? Secondary analyses of the Supreme Nudge parallel cluster-randomised controlled supermarket trial
BackgroundSupermarket interventions are promising to promote healthier dietary patterns, but not all individuals may be equally susceptible. We...
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Health-related quality of life after hip fracture: effects of a 12-month home-based exercise intervention—secondary analyses of an RCT
PurposeIn this randomized controlled trial, we analyzed the effects of a 12-month home-based exercise intervention on the health-related quality of...
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Emotion dysregulation and heart rate variability improve in US veterans undergoing treatment for posttraumatic stress disorder: Secondary exploratory analyses from a randomised controlled trial
BackgroundEmotion regulation (ER) is a key process underlying posttraumatic stress disorder (PTSD), yet, little is known about how ER changes with...
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Impact of primary to secondary care data sharing on care quality in NHS England hospitals
Health information exchange (HIE) is seen as a key component of effective care but remains poorly evidenced at a health system level. In the UK...
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Low vitamin D levels are linked with increased cardiovascular disease risk in young adults: a sub-study and secondary analyses from the ACTIBATE randomized controlled trial
PurposeVitamin D deficiency is related to metabolic disturbances. Indeed, a poor vitamin D status has been usually detected in patients with...
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Systemic Risk Factors for Vitreous Hemorrhage Secondary to Polypoidal Choroidal Vasculopathy
IntroductionIt remains unclear whether systemic factors are associated with an increased risk of vitreous hemorrhage (VH) secondary to polypoidal...
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Associations between app usage and behaviour change in a m-health intervention to improve physical activity and sleep health in adults: secondary analyses from two randomised controlled trials
BackgroundTo examine associations between user engagement and activity-sleep patterns in a 12-week m-health behavioural intervention targeting...
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The effect of exercise training and motivational counselling on physical activity behaviour and psychosocial factors in pregnant women: secondary analyses of the FitMum randomised controlled trial investigating prenatal physical activity
BackgroundA physically active lifestyle is beneficial during pregnancy. However, little is known about physical activity (PA) behaviour and...
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When Does Primary Prevention Encroach on Secondary Prevention?
Purpose of ReviewThe risk of incident atherosclerotic cardiovascular disease (ASCVD) in primary prevention is typically lower than in secondary...
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Exercise-Based Cardiac Rehabilitation: Secondary Data Analyses of Mortality and Working Capacity in Germany, 2010–2017
BackgroundExercise-based cardiac rehabilitation is safe and implemented in international cardiac rehabilitation guidelines. Evidence for long-term...
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Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial
PurposeBenefit from convalescent plasma therapy for coronavirus disease 2019 (COVID-19) has been inconsistent in randomized clinical trials (RCTs)...
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Celiac disease and upper secondary school achievement in Sweden A retrospective cohort study
BackgroundBoth undiagnosed celiac disease and some chronic childhood diseases are associated with lower academic achievement. However, there is...
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Characterization of immunization secondary analyses using demographic and health surveys (DHS) and multiple indicator cluster surveys (MICS), 2006–2018
BackgroundInfant immunization coverage worldwide has plateaued at about 85%. Using existing survey data to conduct analyses beyond estimating...
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Do Spinopelvic Parameters Relate with Secondary Hip Spine Syndrome in Secondary Hip Arthritis?
BackgroundThe prevalence of low back pain (LBP) with primary osteoarthritis (OA) hip undergoing total hip replacement (THA) has been studied....
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Differential posttraumatic stress disorder symptom cluster response to stellate ganglion block: secondary analysis of a randomized controlled trial
Empirically supported treatments for posttraumatic stress disorder (PTSD) exist, but research suggests these therapies are less effective,...
