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The Role of Autoantibody Testing in Modern Personalized Medicine
Personalized medicine (PM) aims individualized approach to prevention, diagnosis, and treatment. Precision Medicine applies the paradigm of PM by...
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Characteristic phenotype of Chinese patients with adult-onset diabetes who are autoantibody positive by 3-Screen ICA™ ELISA
AimsTo assess the prevalence of diabetes-associated autoantibodies in Chinese patients recently diagnosed with adult-onset diabetes and to evaluate...
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Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes
Aims/hypothesisAntibodies specific to oxidative post-translational modifications (oxPTM) of insulin (oxPTM-INS) are present in most individuals with...
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Anti-Ro52 Autoantibody Is Common in Systemic Autoimmune Rheumatic Diseases and Correlating with Worse Outcome when Associated with interstitial lung disease in Systemic Sclerosis and Autoimmune Myositis
This review highlights the 30 plus years research progress since the discovery of autoantibody to Ro52/TRIM21 in patients with systemic lupus...
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Autoantibody-associated psychiatric syndromes in children: link to adult psychiatry
Studies show that psychiatric symptoms in adults and children are sometimes associated with serum neural autoantibodies. The significance of serum...
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Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics
Aims/hypothesisCurrent clinical guidelines for childhood-onset monogenic diabetes outside infancy are mainly focused on identifying and testing for...
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Autoimmune encephalitis: recent clinical and biological advances
In 2015, we wrote a review in The Journal of Neurology summarizing the field of autoantibody-associated neurological diseases. Now, in 2023, we...
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Search for a time- and cost-saving genetic testing strategy for maturity-onset diabetes of the young
AimsCorrect genetic diagnosis of maturity-onset diabetes of the young (MODY) is beneficial for person’s diabetes management compared to no genetic...
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Characterisation of HNF1A variants in paediatric diabetes in Norway using functional and clinical investigations to unmask phenotype and monogenic diabetes
Aims/hypothesisCorrectly diagnosing MODY is important, as individuals with this diagnosis can discontinue insulin injections; however, many people...
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Autoimmune Pulmonary Alveolar Proteinosis: A Review of Pathogenesis and Emerging Therapies
Purpose of ReviewAutoimmune pulmonary alveolar proteinosis is a heterogenous clinical syndrome of disordered surfactant clearance due to a...
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Pathogenesis of autoimmune disease
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell and T cell reactivity to normal constituents of the host....
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The autoantibody-mediated encephalitides: from clinical observations to molecular pathogenesis
The autoimmune encephalitis (AE) syndromes have been characterised by the detection of autoantibodies in serum and/or cerebrospinal fluid which...
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Clinical practice guidelines for molecular tumor markers, 2nd edition review part 1
With advances in gene and protein analysis technologies, many target molecules that may be useful in cancer diagnosis have been reported. Therefore,...
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Multiple refractory intracellular pathogen infections in a human immunodeficiency virus-negative patient with anti-interferon-γ autoantibodies: a case report
BackgroundThe clinical presentation of adult-onset immunodeficiency with anti-interferon (IFN)-γ autoantibodies with intracellular pathogens can be...
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Anti-factor H antibody associated hemolytic uremic syndrome following SARS-CoV-2 infection
BackgroundThe pathogenesis of autoantibody generation in anti-factor H (FH) antibody associated atypical hemolytic uremic syndrome (aHUS) is unknown...
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Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities
Myasthenia gravis is an autoimmune disorder defined by muscle weakness and fatigability associated with antibodies against proteins of the...
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Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare...
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Monogenic diabetes clinic (MDC): 3-year experience
AimIn the pediatric diabetes clinic, patients with type 1 diabetes mellitus (T1D) account for more than 90% of cases, while monogenic forms represent...
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Challenges in blood transfusion caused by anti-Hr0: A rare case of D-- Phenotype in Asia Abstract
IntroductionD–Phenotype is linked to abnormal expression of RHCE gene. Consequently, individuals with this condition may develop antibodies against...
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Urticaria
Urticaria is an inflammatory skin disorder that affects up to 20% of the world population at some point during their life. It presents with wheals,...
