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Dystrophin genetic variants and autism
Loss-of-function variants in the dystrophin gene, a well-known cause of muscular dystrophies, have emerged as a mutational risk mechanism for autism...
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Does lumbar lordosis minus thoracic kyphosis predict the clinical outcome of patients with adult degenerative scoliosis?
PurposeTo evaluate the predictive effect of lumbar lordosis minus thoracic kyphosis (LL-TK) in the surgical outcome of adult degenerative scoliosis...
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Phenytoin, Valproat, Levetiracetam und Lacosamid im Status epilepticus
Benzodiazepine refractory or established status epilepticus (ESE) is defined as ongoing seizure activity despite the use of benzodiazepines. In...
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Current radiotracers to image neurodegenerative diseases
The term of neurodegenerative diseases covers a heterogeneous group of disorders that are distinguished by progressive degeneration of the structure...
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Improving Outcomes in Infantile Spasms: Role of Pharmacotherapy
Infantile spasms, and specifically within the context of West syndrome , is one of the most common epileptic encephalopathies to occur in early...
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Pharmacotherapy for Dravet Syndrome
Dravet syndrome (DS) is an intractable pediatric epilepsy syndrome, starting in early childhood. This disorder typically manifests with febrile...
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International Veterinary Epilepsy Task Force consensus proposal: medical treatment of canine epilepsy in Europe
In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions...
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Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex
Prepulse inhibition (PPI) is an example of sensorimotor gating and deficits in PPI have been demonstrated in schizophrenia patients. Phencyclidine...
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Synaptisches Vesikelprotein 2A
Both levetiracetam (LEV) and brivaracetam (BRV) specifically bind to the synaptic vesicle protein 2A (SV2A). Synaptic vesicle protein 2A is part of...
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Use of the newer antiepileptic drugs in pediatric epilepsies
Children with epilepsy, particularly infants, differ from adults not only in the clinical manifestations of their seizures but also in the presence...
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Azimilide for Atrial Fibrillation: Clinical Trial Results and Implications
Azimilide dihydrochloride (or azimilide) is a class III antiarrhythmic drug currently under investigation that has been tested in atrial fibrillation...