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  1. Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy

    Purpose

    The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein...

    Maria Elisa Serrano, Mohamed Ali Bahri, ... Alain Plenevaux in Molecular Imaging and Biology
    Article Open access 23 March 2020

  2. Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities

    Myasthenia gravis is an autoimmune disorder defined by muscle weakness and fatigability associated with antibodies against proteins of the...

    Natalie Rose, Sebastian Holdermann, ... Tobias Derfuss in Acta Neuropathologica
    Article Open access 08 September 2022

  3. Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy

    Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often precede the onset of motor symptoms, and have a negative impact...

    Lluis Miquel-Rio, Diana Alarcón-Arís, ... Analia Bortolozzi in Translational Psychiatry
    Article Open access 24 February 2022

  4. Proteomic identification of select protein variants of the SNARE interactome associated with cognitive reserve in a large community sample

    Age-related neuropathologies progressively impair cognitive abilities by damaging synaptic function. We aimed to identify key components within the...

    Alfredo Ramos-Miguel, Andrea A. Jones, ... William G. Honer in Acta Neuropathologica
    Article 01 March 2021

  5. Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism

    Mutations in many synaptic genes are associated with autism spectrum disorders (ASD), suggesting that synaptic dysfunction is a key driver of ASD...

    Le Wang, Vincent R. Mirabella, ... Zhi** P. Pang in Molecular Psychiatry
    Article 24 October 2022

  7. Fibroblast-Secreted Phosphoprotein 1 Mediates Extracellular Matrix Deposition and Inhibits Smooth Muscle Cell Contractility in Marfan Syndrome Aortic Aneurysm

    Fibrillin 1 (Fbn1) mutation causes Marfan syndrome (MFS) with thoracic aortic aneurysm (TAA) as the main complication. The mechanisms for...

    Mei Zhou, Yuexin Zhu, ... Jie Du in Journal of Cardiovascular Translational Research
    Article 12 April 2022

  8. At a Glance: An Update on Neuroimaging and Retinal Imaging in Alzheimer’s Disease and Related Research

    Neuroimaging serves a variety of purposes in Alzheimer’s disease (AD) and related dementias (ADRD) research — from measuring microscale neural...

    J. Ford, D. Kafetsouli, ... Lefkos T. Middleton in The Journal of Prevention of Alzheimer's Disease
    Article Open access 17 January 2022

  9. Positive modulation of NMDA receptors by AGN-241751 exerts rapid antidepressant-like effects via excitatory neurons

    Dysregulation of the glutamatergic system and its receptors in medial prefrontal cortex (mPFC) has been implicated in major depressive disorder....

    Santosh Pothula, Rong-Jian Liu, ... Ronald S. Duman in Neuropsychopharmacology
    Article 15 October 2020

  11. SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer’s disease

    Dysfunctional RNA-binding proteins (RBPs) have been implicated in several neurodegenerative disorders. Recently, this paradigm of RBPs has been...

    Neelam Younas, Saima Zafar, ... Inga Zerr in Acta Neuropathologica
    Article Open access 23 June 2020
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