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Expression of NLRP3 and superoxide dismutase-2 (SOD2) in the gingival tissues of periodontitis patients with and without type 2 diabetes mellitus: a case–control study
ObjectiveTo evaluate the interaction between the NLRP3 inflammasome and superoxide dismutase-2 (SOD2) to provide an insight into the complex host...
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SOD2 Alleviates Hearing Loss Induced by Noise and Kanamycin in Mitochondrial DNA4834-deficient Rats by Regulating PI3K/MAPK Signaling
Superoxide dismutase 2 (SOD2)-mediated gene therapy has significant protective effects against kanamycin-induced hearing loss and hair cell loss in...
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Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes
ObjectiveThere is a growing body of evidence indicating that pyroptosis, a programmed cell death mechanism, plays a crucial role in the exacerbation...
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SIRT3-Mediated SOD2 and PGC-1α Contribute to Chemoresistance in Colorectal Cancer Cells
BackgroundAnticancer drugs generate excessive reactive oxygen species (ROS), which can cause cell death. Cancer cells can resist this oxidative...
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Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway
PurposeAtherosclerosis, a chronic disease of the arteries, results from pathological processes including the accumulation and aggregation of oxidized...
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Superoxide dismutase 2 as a predictor in patients with hepatitis B virus-associated acute-on-chronic liver failure
The prognosis of hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is critical in clinical management. We aimed to assess the...
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Differential association of antioxidative defense genes with white matter integrity in youth bipolar disorder
Oxidative stress is associated with white matter diffusion metrics in adults with bipolar disorder (BD). We examined the association of...
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Targeting high glucose-induced epigenetic modifications at cardiac level: the role of SGLT2 and SGLT2 inhibitors
BackgroundSodium-glucose co-transporters (SGLT) inhibitors (SGLT2i) showed many beneficial effects at the cardiovascular level. Several mechanisms of...
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Anoikis patterns via machine learning strategy and experimental verification exhibit distinct prognostic and immune landscapes in melanoma
BackgroundAnoikis is a cell death programmed to eliminate dysfunctional or damaged cells induced by detachment from the extracellular matrix....
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SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b+ cells
BackgroundHigh prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia...
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Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma
Rapid development of drug resistance after chemotherapy is a major cause of treatment failure in individuals with pancreatic ductal adenocarcinoma...
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Ethanol extract of Paridis rhizoma attenuates carrageenan-induced paw swelling in rats by inhibiting the production of inflammatory factors
ContextInflammation has been identified as a key factor contributing to the development of numerous diseases. Several anti-inflammatory drugs have...
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Involvement of the Sch9/Rim15/Msn2 signaling pathway in the anti-aging activity of dendrobine from Dendrobium nobile Lindl. via modification of oxidative stress and autophagy
BackgroundAging is an important pathogenic factor of age-related diseases and has brought huge health threat and economic burden to the society. Dendr...
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Genetic variability of oxidative stress and DNA repair genes associated with pre-treatment cancer-related fatigue in women with breast cancer
PurposeInvestigate potential relationships between pre-treatment cancer-related fatigue (CRF) in women with early-stage breast cancer and variation...
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Expressions of mitochondria-related genes in pregnant women with subclinical hypothyroidism, and expressions of miRNAs in maternal and cord blood
BackgroundSubclinical hypothyroidism in pregnancy and definition by upper thyrotropin (TSH) cutoff are controversial. As mitochondria are influenced...
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Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression
BackgroundPrevious studies have revealed that Sirt3 deficiency is associated with several inflammatory responses. The purpose of this study is to...
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Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss
PurposeThe purpose of our study is to investigate the function of YAP1 in the trophoblast ferroptosis and maternal-fetal interface communication of...
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Meta-analysis of endometrial transcriptome data reveals novel molecular targets for recurrent implantation failure
PurposeGene expression analysis of the endometrium has been shown to be a useful approach for identifying the molecular signatures and pathways...
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Superoxide dismutase isozymes in cerebral organoids from autism spectrum disorder patients
Autism spectrum disorder is a pervasive neurodevelopmental disorder with a substantial contribution to the global disease burden. Despite intensive...
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Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats
ObjectiveTo explore the protective effect and mechanism of Kuntai (KT) Capsule on angiotensin II (Ang II)-induced hypertension in ovariectomized...