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1. Quantitative detection of methylated SOCS-1 in schizophrenia and bipolar disorder considering SOCS-1 -1478CA/del polymorphism and clinical parameters

   Background

   We aimed to investigate the quantitative detection of methylated suppressor of cytokine signaling-1 ( SOCS-1 ) in schizophrenia (SCZ) and...

   Hasan Mervan Aytac, Sacide Pehlivan, ... Yasemin Oyaci in Irish Journal of Medical Science (1971 -)

   Article 20 May 2022

2. Alterations of SOCS1 and SOCS3 transcript levels, but not promoter methylation levels in subcutaneous adipose tissues in obese women

   Background

   Animal model studies suggest that change in the members of the suppressor of the cytokine signaling (SOCS) family (mainly SOCS1 and SOCS3)...

   Solaleh Emamgholipour, Fataneh Esmaeili, ... Mehrnoosh Shanaki in BMC Endocrine Disorders

   Article Open access 06 January 2023
   

3. MicroRNAs and target molecules in bladder cancer

   Bladder cancer (BC) is considered as one of the most common malignant tumors in humans with complex pathogenesis including gene expression variation,...

   Payam Kheirmand Parizi, Fereshteh Yarahmadi, ... Seyed-Alireza Esmaeili in Medical Oncology

   Article 20 November 2020
   

4. Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules

   To enhance understanding of polycystic ovary syndrome (PCOS) at the molecular level; this investigation intends to examine the genes and pathways...

   Praveenkumar Devarbhavi, Lata Telang, ... Iranna Kotturshetti in Reproductive Biology and Endocrinology

   Article Open access 23 February 2021
   

5. Noncoding RNAs associated with IgA nephropathy

   IgA nephropathy (IgAN) is one of the most common glomerulonephritides. The disease is characterized by haematuria, proteinuria, deposition of...

   Sangeetha P. Kademani, Prabhudas Nelaturi, ... Sambandam Ravikumar in Journal of Nephrology

   Article 10 December 2022
   

6. Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

   The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane...

   Chen Xue, Qinfan Yao, ... Lanjuan Li in Signal Transduction and Targeted Therapy

   Article Open access 19 May 2023
   

7. Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

   Background

   Polymorphonuclear neutrophils (PMNs) play an important role in sepsis-related acute lung injury (ALI). Accumulating evidence suggests...

   Yang Jiao, Ti Zhang, ... Xueyin Shi in Critical Care

   Article Open access 12 October 2021
   

8. Role of miRNAs in macrophage-mediated kidney injury

   Macrophages, crucial components of the human immune system, can be polarized into M1/M2 phenotypes, each with distinct functions and roles....

   Junxin Li, **da Yan, ... Shurong Wang in Pediatric Nephrology

   Article 27 May 2024
   

9. N6-methyladenosine RNA modifications: a potential therapeutic target for AML

   N6-methyladenosine (m6A) RNA modification has recently emerged as an essential regulator of normal and malignant hematopoiesis. As a reversible...

   Rong Hu, Peiyun Liao, ... Yuhua Li in Annals of Hematology

   Article 07 August 2023
   

10. Pharmacological potentiation of monocyte-derived dendritic cell cancer immunotherapy

    Dendritic cells have been at the forefront of cancer-immunotherapy research for over 2 decades. They elicited that attention by having an...

    Alexandre Poirier, Michel L. Tremblay in Cancer Immunology, Immunotherapy

    Article 28 November 2022
    

11. Scope of JAK Inhibitors in Children: Recent Evidence and Way Forward

    Over the last decade, there has been an increase in the use of targeted therapy using small molecules such as Janus kinase (JAK) inhibitors. Since...

    Narendra Kumar Bagri, Christine Chew, A. V. Ramanan in Pediatric Drugs

    Article 29 September 2023
    

12. Tumor-derived miRNAs as tumor microenvironment regulators for synergistic therapeutic options

    MicroRNAs (miRNAs) are a class of non-coding RNAs that perform post-transcriptional gene regulation. This review focuses on the role of tumor...

    Qiuxing Meng, Yaoming Deng, ... Shifu Tang in Journal of Cancer Research and Clinical Oncology

    Article 15 November 2022
    

13. The functions of N6-methyladenosine (m6A) RNA modifications in colorectal cancer

    Colorectal cancers (CRC), which includes colon cancer (CC) and rectal cancer (RC), are some of the most common malignant tumors that are prone to...

    Haiyan Qiao, Linfeng Liu, ... Liang Wang in Medical Oncology

    Article 29 September 2022
    

14. Small molecule inhibitors targeting m⁶A regulators

    As the most common form of epigenetic regulation by RNA, N ⁶ methyladenosine (m ⁶ A) modification is closely involved in physiological processes, such...

    Guotai Feng, Yongya Wu, ... Guan Wang in Journal of Hematology & Oncology

    Article Open access 06 May 2024
    

15. Metabolic hallmarks of natural killer cells in the tumor microenvironment and implications in cancer immunotherapy

    Natural killer (NK) cells belong to the early responder group against cancerous cells and viral infection. Emerging evidence reveals that distinct...

    Yuqing Yang, Lin Chen, ... Shengtao Zhou in Oncogene

    Article 06 December 2022
    

16. M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics

    Background

    N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation,...

    Yurong Huang, Qiuyun Xue, ... Chenggui Miao in Arthritis Research & Therapy

    Article Open access 02 October 2023
    

17. Platelets in Kawasaki disease: mediators of vascular inflammation

    Kawasaki disease, a systemic vasculitis that affects young children and can result in coronary artery aneurysms, is the leading cause of acquired...

    Magali Noval Rivas, Begüm Kocatürk, ... Moshe Arditi in Nature Reviews Rheumatology

    Article 17 June 2024
    

18. Interplay between signal transducers and activators of transcription (STAT) proteins and cancer: involvement, therapeutic and prognostic perspective

    Signal transducers and activators of transcription or STAT are proteins that consist of various transcription factors that are responsible for...

    Nandana Jill, Sannidhi Bhootra, ... Koustav Sarkar in Clinical and Experimental Medicine

    Article 29 September 2023
    

19. Role of m⁶A modifications in immune evasion and immunotherapy

    RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N ⁶ -methyladenosin...

    Chunyu Wu, Lvyuan Li, ... Wei **ong in Medical Oncology

    Article 18 May 2024
    

20. The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies

    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diverse serological autoantibodies. Anti-dsDNA antibodies are...

    Yaqi Wang, Shengxiang **ao, ... Huixia Wang in Clinical Reviews in Allergy & Immunology

    Article Open access 20 September 2021