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Impact of immunohistochemistry staining conditions on the incidence of human epidermal growth factor receptor 2 (HER2)-low breast cancer
We investigated frequencies of HER2-low breast cancer (BC) (immunohistochemistry [IHC] 1+ or 2+ without gene amplification) before and after IHC...
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Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status
BackgroundHuman epidermal growth factor receptor 2 (HER2)-low status has recently gained attention because of the potential therapeutic benefits of...
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HER2 copy number determination in breast cancer using the highly sensitive droplet digital PCR method
Human epidermal growth factor receptor 2 (HER)-positive breast cancer (BC) is characterized by an aggressive clinical course. In the case of HER2...
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Clinical implications and chemo-sensitivity of adjuvant chemotherapy in patients with poorly cohesive cells-gastric cancer
PurposePoorly cohesive cells-gastric cancer (PCC-GC) represents distinct features within the GC spectrum. The present study investigated the...
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Comprehensive Young Age Breast Cancer registry from clinical, genomics, and patient-reported outcomes measured with 15 years follow-up: the CHARM cohort profile
BackgroundIn recognition of the distinct clinical challenges and research gaps in young breast cancer (YBC) patients, we established the...
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Comparison of breast cancer HER-2 receptor testing with immunohistochemistry and in situ hybridization
PurposeHuman epidermal growth factor receptor–2 (HER2) status can be tested with immunohistochemistry (IHC) and in situ hybridization (ISH). The 2018...
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Subtypes of high-grade breast ductal carcinoma in situ (DCIS): incidence and potential clinical impact
ObjectiveThe purpose of this study was to investigate and classify the molecular subtypes of high-grade ductal carcinoma in situ (DCIS) and identify...
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Effect of HER2/CEP17 ratio on survival in metastatic HER2-positive gastric cancer, multicenter study
AimHER2-positive metastatic gastric cancer is still a highly fatal disease despite advances. We aimed to investigate the relationship between...
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Clinicopathological and prognostic value of calcification morphology descriptors in ductal carcinoma in situ of the breast: a systematic review and meta-analysis
BackgroundCalcifications on mammography can be indicative of breast cancer, but the prognostic value of their appearance remains unclear. This...
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Early experience of robotic axillary lymph node dissection in patients with node-positive breast cancer
BackgroundRobotic surgical systems enable surgeons to perform precise movement in the surgical field using high-resolution 3D vision and flexible...
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Evaluation of the relationship between Ki67 expression level and neoadjuvant treatment response and prognosis in breast cancer based on the Neo-Bioscore staging system
BackgroundNeoadjuvant chemotherapy (NAC) is widely used in the treatment of primary breast cancer. Different staging systems have been developed to...
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Correlation of tumour subtype with long-term outcome in small breast carcinomas: a Swedish population-based retrospective cohort study
PurposeTo investigate if molecular subtype is associated with outcome in stage 1 breast cancer (BC).
MethodsTissue samples from 445 women with...
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Prognostic factors in non-metastatic HER2 ‘low’ and HER2 ‘negative’ breast cancer: single institute experience
AimComparison of prognosis and survival in human epidermal growth factor receptor 2 (HER2)-low and HER2-negative patients with early stage or locally...
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Date Palm as Source of Nutraceuticals for Health Promotion: a Review
Purpose of ReviewChronic diseases are problematic to health professional specially when using drugs throughout the course of life with un-tolerated...
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Efficacy of sentinel lymph-node biopsy after neoadjuvant chemotherapy in clinically axilla node-negative patients
PurposeBreast cancer is the most common cancer in women. Developments in breast cancer treatment have extended the life expectancy of these patients,...
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Deciphering clinical significance of BCL11A isoforms and protein expression roles in triple-negative breast cancer subtype
PurposeTriple negative breast cancer (TNBC) is an aggressive clinical tumor, accounting for about 25% of breast cancer (BC) related deaths....
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Lymphovascular Invasion as a Predictive Factor for Recurrence in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is relatively more aggressive than other subtypes of breast cancer. Lymphovascular invasion (LVI) is a...
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Prognostic factors after isolated ipsilateral local and regional recurrence in HER2-negative luminal breast cancer: a multi-center retrospective study
BackgroundAlthough the incidence of isolated ipsilateral local and regional recurrence (IILRR) in human epidermal growth factor 2 (HER2)-negative...
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Surgical margin status and survival outcomes of breast cancer patients treated with breast-conserving surgery and whole-breast irradiation after neoadjuvant chemotherapy
PurposeThe definition of "no tumor on ink" is generally applied for clear resection margin (RM) after breast-conserving surgery (BCS). However, few...
