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An assessment of the psychometric properties of the Co** Strategies Questionnaire – Sickle Cell Disease (CSQ-SCD) among adults in the United States
BackgroundPrevious studies have reported conflicting factor structures of the Co** Strategies Questionnaire - Sickle Cell Disease (CSQ-SCD). This...
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Psychiatric symptoms in a female with subacute combined degeneration of the spinal cord (SCD): a case report
BackgroundSubacute combined degeneration of the spinal cord (SCD) is mainly caused by deficiency of Vitamin B12 and characterized by deep...
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Expert consensus on the management of infusion-related reactions (IRRs) in patients with sickle cell disease (SCD) receiving crizanlizumab: a RAND/UCLA modified Delphi panel
Crizanlizumab, a monoclonal antibody against P-selectin, has been shown to reduce vaso-occlusive crises (VOCs) compared to placebo in patients ≥ 16...
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The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study
BackgroundThe life expectancy for individuals with sickle cell disease (SCD) has greatly increased over the last 50 years. Adults with SCD experience...
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Mindfulness-based stress reduction for community-dwelling older adults with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) in primary care: a mixed-methods feasibility randomized control trial
BackgroundPrimary care is often the first point of contact when community-dwelling older adults experience subjective cognitive decline (SCD) or mild...
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Assessment of Comorbidity Burden and Treatment Response: Reanalysis of the SCD-HEFT Trial
IntroductionComorbidity burden may be associated with treatment-effect heterogeneity (HTE) in clinical trials, which could alter the interpretation...
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Exosome-mediated delivery of SCD-1 siRNA promoted the death of anaplastic thyroid carcinoma cells via regulating ROS level
PurposeAnaplastic thyroid carcinoma (ATC) is one of the most aggressive cancers in the world. Stearoyl-CoA desaturase-1 (SCD-1) is one of major...
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The clinical and radiological effectiveness of autologous bone marrow derived osteoblasts (ABMDO) in the management of avascular necrosis of femoral head (ANFH) in sickle cell disease (SCD)
PurposeAvascular necrosis of the femoral head is a common issue faced by orthopaedic surgeons that ranges between 10 and 18%, but in patients with...
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Improvement of SCD morbimortality in children: experience in a remote area of an African country
BackgroundSickle cell disease (SCD) is a public health problem in the Democratic Republic of Congo. While reference sickle cell centers have been...
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SCD leads to the development and progression of acute myocardial infarction through the AMPK signaling pathway
BackgroundAcute myocardial infarction (AMI) is myocardial necrosis caused by acute coronary ischemia and hypoxia. It can be complicated by...
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Gardening and subjective cognitive decline: a cross-sectional study and mediation analyses of 136,748 adults aged 45+ years
BackgroundGiven the benefits of gardening for physical and psychological health, we explored whether gardening was associated with lower risks of...
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Death due to sickle cell crisis: a case report
Sickle cell disease (SCD) is the most common hereditary hemoglobinopathy worldwide. It results in characteristic acute and chronic findings on...
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Caught between pity, explicit bias, and discrimination: a qualitative study on the impact of stigma on the quality of life of persons living with sickle cell disease in three African countries
PurposeSickle cell disease (SCD) is an inherited blood disorder characterized by unpredictable episodes of acute pain and numerous health...
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Impact and burden of sickle cell disease in critically ill obstetric patients in a high dependency unit in Sierra Leone—a registry based evaluation
IntroductionSickle cell disease (SCD) in pregnancy is associated with worse maternal and neonatal outcomes. There is limited available data...
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Social determinants of health and treatment center affiliation: analysis from the sickle cell disease implementation consortium registry
BackgroundAdults with sickle cell disease (SCD) suffer early mortality and high morbidity. Many are not affiliated with SCD centers, defined as no...
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Usefulness of the autism spectrum quotient (AQ) in screening for autism spectrum disorder and social communication disorder
BackgroundIn the Diagnostic and Statistical Manual and Mental Disorders, Fifth Edition (DSM-5), autism spectrum disorder (ASD) and social (pragmatic)...
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Health education to promote knowledge about sickle cell disease and newborn screening in pregnant women: a community-based pilot study using the healthy beginning initiative
BackgroundPregnancy presents a critical period for any maternal and child health intervention that may impact the health of the newborn. With low...
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Kidney failure outcomes in children and young adults with sickle cell disease in the United States Renal Data System
BackgroundChildren and young adults with sickle cell disease (SCD) develop kidney disease early in childhood, with some patients progressing to...
