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A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA
BackgroundCurrently, standard treatments for chronic hepatitis B such as nucleos(t)ide analogs (NAs), effectively reduce hepatitis B virus (HBV)...
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Protein neddylation and its role in health and diseases
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine...
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Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely...
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Serum pepsinogen levels in different regions of China and its influencing factors: a multicenter cross-sectional study
BackgroundThe aim of this study is to investigate the difference of serum pepsinogen (PG) baseline levels in different regions of China and its...
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Efficacy of acupuncture in treating chronic non-specific low back pain
ObjectiveTo provide an update on the evidence of the effectiveness of acupuncture in treating chronic non-specific low back pain (CNSLBP) based on...
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Human placental mesenchymal stromal cells are ciliated and their ciliation is compromised in preeclampsia
BackgroundThe development of the human placenta is tightly coordinated by a multitude of placental cell types, including human chorionic villi...
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Development of mental health first-aid guidelines for a person after a potentially traumatic event: A Delphi expert consensus study in Argentina and Chile
BackgroundExposure to potentially traumatic events increases the risk of a person develo** a mental disorder. Training community members to offer...
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Prediction of adverse drug reactions based on knowledge graph embedding
BackgroundAdverse drug reactions (ADRs) are an important concern in the medication process and can pose a substantial economic burden for patients...
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The Gothenburg H70 Birth cohort study 2014–16: design, methods and study population
To improve health care for older persons, we need to learn more about ageing, e.g. identify protective factors and early markers for diseases. The...
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Primary cilia in hard tissue development and diseases
Bone and teeth are hard tissues. Hard tissue diseases have a serious effect on human survival and quality of life. Primary cilia are protrusions on...
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Knee Dislocations in Sports Injuries
Knee dislocations are devastating when they occur on the athletic field or secondary to motor sports. The complexity of presentation and spectrum of...
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Caveolin proteins: a molecular insight into disease
Caveolae are a kind of specific cystic structures of lipid rafts in the cytoplasmic membrane and are rich in cholesterol and sphingolipids. In recent...
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Assessment of functional lung impairment in patients with thyroid disorders
Background and objectiveMany thyroid diseases can lead to pulmonary problems. Hypothyroidism reduces respiratory drive and can cause obstructive...