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Antioxidant and anticholinesterase activity of rutin in aluminum chloride-exposed Drosophila melanogaster
Aluminum (Al) toxicity has been associated with multiple neurodegenerative disorders, including Alzheimer’s disease (AD). Since current medications...
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Aflatoxin B1-induced hepatorenal impairment in rats via oxidative/inflammatory damage is accompanied by altered purinergic and kynurenine pathways: protective effect of rutin
PurposeThis study investigated the protective effects of rutin against the hepatorenal toxicity of aflatoxin B1 (AFB1) exposure in rats.
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Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: possible therapeutic intervention of rutin and quercetin
Diabetic nephropathy and peripheral neuropathy are the two main complications of chronic diabetes that contribute to high morbidity and mortality....
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The ameliorating effect of Rutin on hepatotoxicity and inflammation induced by the daily administration of vortioxetine in rats
BackgroundVortioxetine (VORTX) is a potent and selective type of selective serotonin reuptake inhibitor (SSRI) that is mainly prescribed for treating...
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Green synthesis of silver nanoparticles using dietary antioxidant rutin and its biological contour
BackgroundDietary and wholesome antioxidant rutin is considered advantageous due to its potential protective role for numerous diseases related to...
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Combination of Enzymes and Rutin to Manage Osteoarthritis Symptoms: Lessons from a Narrative Review of the Literature
AbstractOsteoarthritis is the most common joint disorder affecting over 300 million people worldwide. It typically affects the knees and the hips,...
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Analysis of human aldehyde dehydrogenases (ALDH) gene expression pattern in breast cancer tissue samples: rutin-copper complex inhibit the breast cancer cell proliferation
BackgroundHigher aldehyde dehydrogenases ( ALDH ) activity is one of the important signatures of breast cancer appearance and has been associated with...
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Regulation of iodine-glucose flip-flop in SW1736 anaplastic thyroid cancer cell line
Aims and backgroundThe alternative manner of iodide and glucose uptake found in different types of thyroid cancer, referred to flip-flop. ATC cells...
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Determination of Rutin's antitumoral effect on EAC solid tumor by AgNOR count and PI3K/AKT/mTOR signaling pathway
Rutin is one of the flavonoids found in fruits and vegetables. The PI3K/AKT/mTOR signaling pathway is critical for the life cycle at the cellular...
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An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin
BackgroundCurcumin, quercetin and rutin are flavonoids having strong antioxidant potential, individually used in treatment of numerous ailments. The...
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Phytoconstituents of Artemisia annua as potential inhibitors of SARS CoV2 main protease: an in silico study
BackgroundIn November 2019, the world faced a pandemic called SARS-CoV-2, which became a major threat to humans and continues to be. To overcome...
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Depletion of β-sitosterol and enrichment of quercetin and rutin in Cissus quadrangularis Linn fraction enhanced osteogenic but reduced osteoclastogenic marker expression
BackgroundCissus quadrangularis Linn. (CQ) has been used in Indian and Thai traditional medicine for healing bone fractures because of numerous...
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Insight into antioxidant-like activity and computational exploration of identified bioactive compounds in Talinum triangulare (Jacq.) aqueous extract as potential cholinesterase inhibitors
BackgroundRecent reports have highlighted the significance of plant bioactive components in drug development targeting neurodegenerative disorders...
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Effect of rutin on retinal VEGF, TNF-α, aldose reductase, and total antioxidant capacity in diabetic rats: molecular mechanism and ocular pharmacokinetics
PurposeThe current study was conducted to explore the potential of rutin in preventing sight-threatening diabetic retinopathy.
Methods ...
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Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis
ObjectiveTo quantify phytochemicals using liquid chromatography and mass spectroscopy (LCMS) analysis and explore the therapeutic effect of Aesculus...
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Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats
BackgroundNatural extracts with beneficial biological activities are nowadays of high interest, in various treatment or prophylaxis. Hypericum...
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Molecular interaction of bioactive compounds from Senecio biafrae leaf with α-amylase and α-glucosidase receptors
BackgroundDiabetes mellitus is one of the silent killer diseases affecting millions of people globally and some of the key enzymes in managing this...
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Evaluating anthelmintic, anti-platelet, and anti-coagulant activities, and identifying the bioactive phytochemicals of Amaranthus blitum L.
BackgroundHighlighting affordable alternative crops that are rich in bioactive phytoconstituents is essential for advancing nutrition and ensuring...
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Anti-protein glycation and free-radical scavenging properties of Sri Lankan antidiabetic medicinal plant Salacia reticulata l. (Kothala Himbutu)
BackgroundDecoctions of the root and stem of the medicinal plant Salacia reticulata is an indigenous remedy for diabetics and its complications in...
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Advances in the molecular mechanism and targeted therapy of radioactive-iodine refractory differentiated thyroid cancer
Most patients with differentiated thyroid cancer have a good prognosis after radioactive iodine-131 treatment, but there are still a small number of...
