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Molecular diagnosis of trypanosomatids in Didelphis marsupialis from Los Montes de María: a first report of Trypanosoma rangeli from Colombian Caribbean region
Didelphis marsupialis is a primary reservoir of Trypanosoma cruzi , etiologic agent of American Trypanosomiasis-AT or Chagas Disease-CD, in America....
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Remembering Edmund Klein: the Father of Immunotherapy
Edmund Klein’s seminal research in oncology transformed medicine. He would now be 100 years old. This extraordinary physician–scientist has been...
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Transducin Beta-Like 2 is a Potential Driver Gene that Adapts to Endoplasmic Reticulum Stress to Promote Tumor Growth of Lung Adenocarcinoma
BackgroundEndoplasmic reticulum (ER) stress has a close relation with cancer progression. Blocking the adaptive pathway of ER stress could be an...
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Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines
PurposeNKG2A, an inhibitory receptor expressed on NK cells and T cells, leads to immune evasion by binding to HLA-E expressed on cancer cells. Here,...
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Cytogenetic and epidemiological profile of chronic myeloid leukemia in Morocco
Chronic myeloid leukemia (CML) is a neoplastic disease of genetic origin resulting from clonal proliferation of hematopoietic stem cells (HSCs). The...
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Anti-cancer effects of DHP107 on canine mammary gland cancer examined through in-vitro and in-vivo mouse xenograft models
BackgroundCanine mammary gland cancer (CMGC) is a common neoplasm in intact bitches. However, the benefit of adjuvant chemotherapy is unclear. The...
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Olaparib enhances sensitization of BRCA-proficient breast cancer cells to x-rays and protons
PurposeThis study aimed to compare the radiosensitizing effect of the PARP inhibitor, Olaparib, between proton and X-rays irradiations in...
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Characterization, cellular uptake in Caco-2 cells and physiologically based pharmacokinetic modeling of baicalin-loaded solid lipid nanoparticles
BackgroundBaicalin is a natural compound having intriguing and useful pharmacological properties that may be used alone or in conjunction with other...
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In vitro results with minimal blood toxicity of a combretastatin A4 analogue
Cancer is a disease caused by uncontrolled cell growth that is responsible for several deaths worldwide. Breast cancer is the most common type of...
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PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
Protein kinase C (PKC) is activated downstream of gain-of-function GNAQ or GNA11 ( GNAQ/GNA11 ) mutations in over 90% of uveal melanoma (UM). Phase I...
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First insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugs
BackgroundThe combined application of predatory fungi and antiparasitic drugs is a sustainable approach for the integrated control of animal...
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Biased data, biased AI: deep networks predict the acquisition site of TCGA images
BackgroundDeep learning models applied to healthcare applications including digital pathology have been increasing their scope and importance in...
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Diagnostic model development for schizophrenia based on peripheral blood mononuclear cell subtype-specific expression of metabolic markers
A significant proportion of the personal and economic burden of schizophrenia can be attributed to the late diagnosis or misdiagnosis of the...
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Anti-cancer effect of palmatine through inhibition of the PI3K/AKT pathway in canine mammary gland tumor CMT-U27 cells
Canine mammary gland tumors (CMTs) are the most common and lethal cancers in female dogs. Dysregulated phosphoinositide 3-kinases (PI3K)/AKT pathway...
