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Descending serotonergic modulation from rostral ventromedial medulla to spinal trigeminal nucleus is involved in experimental occlusal interference-induced chronic orofacial hyperalgesia
BackgroundDental treatment associated with unadaptable occlusal alteration can cause chronic primary myofascial orofacial pain. The serotonin (5-HT)...
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Alterations in pain processing circuitries in episodic migraine
BackgroundThe precise underlying mechanisms of migraine remain unknown. Although we have previously shown acute orofacial pain evoked changes within...
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Homologies of spinal ascending nociceptive pathways between rats and macaques: can we transpose to human? A review and analysis of the literature
PurposeDue to the difficulty of using neural tracers in humans, knowledge of the nociceptive system’s anatomy is mainly derived from studies in...
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Evidence of Potential Mechanisms of Acupuncture from Functional MRI Data for Migraine Prophylaxis
Purpose of ReviewTo summarize the clinical neuroimaging evidence pertaining to the potential mechanisms of acupuncture for migraine prophylaxis.
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Central stress pathways in the development of cardiovascular disease
PurposeMental stress is of essential consideration when assessing cardiovascular pathophysiology in all patient populations. Substantial evidence...
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Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study
BackgroundRecent resting-state fMRI studies demonstrated functional dysconnectivity within the central pain matrix in migraineurs. This study aimed...
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The Effect of Perioperative Auditory Stimulation with Music on Procedural Pain: A Narrative Review
Purpose of ReviewMusic therapy has seen increasing applications in various medical fields over the last decades. In the vast range of possibilities...
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Study on reverse transsynaptic virus tracing targeting Shenmen (HT7) and heart in mice
ObjectiveTo investigate the neural connections between Shenmen (HT7)-heart and the brain by observing the tracing viruses co-labeled brain nuclear...
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Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain
Trigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of...
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Light Therapy in Chronic Migraine
Purpose of ReviewThis review assesses the effectiveness and safety of light therapy, particularly green light therapy, as an emerging...
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Inadvertent hypothermia: a prevalent perioperative issue that remains to be improved
Inadvertent hypothermia, defined as a body temperature lower than 36 °C, remains to be a critical issue during the perioperative period. Despite of...
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Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review
BackgroundThe premonitory phase, or prodrome, of migraine, provides valuable opportunities to study attack initiation and for treating the attack...
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Neural Control of REM Sleep and Motor Atonia: Current Perspectives
Purpose of ReviewSince the formal discovery of rapid eye movement (REM) sleep in 1953, we have gained a vast amount of knowledge regarding the...
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Placebo and nocebo effects: from observation to harnessing and clinical application
Placebo and nocebo effects are salubrious benefits and negative outcomes attributable to non-specific symbolic components. Leveraging advanced...
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Sleep disturbances associated with DPPX autoantibodies: a case series
Study objectivesTo describe a case series of patients with prominent sleep disturbances and their polysomnography findings in six patients with...
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Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms
Nociplastic pain is a mechanistic term used to describe pain that arises or is sustained by altered nociception, despite the absence of tissue...
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Wrist–ankle acupuncture attenuates cancer-induced bone pain by regulating descending pain-modulating system in a rat model
BackgroundCancer-induced bone pain (CIBP) presents a multiple-mechanism of chronic pain involving both inflammatory and neuropathic pain, and its...
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Bicentre, randomized, parallel-arm, sham-controlled trial of transcranial direct-current stimulation (tDCS) in the treatment of palliative care patients with refractory cancer pain
BackgroundPain is a common symptom in palliative care cancer patients and is often insufficiently relieved. In recent years, transcranial...
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Instrumental assessment of pressure pain threshold over trigeminal and extra-trigeminal area in people with episodic and chronic migraine: a cross-sectional observational study
BackgroundCentral and peripheral sensitization are characterized by widespread hyperalgesia that is manifested by larger pain extent area and...
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Hyperhidrosis: A Central Nervous Dysfunction of Sweat Secretion
Hyperhidrosis (HH) is a central nervous dysfunction characterized by abnormally increased sweating due to a central dysregulation of sweat secretion....
