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Rhein suppresses esophageal cancer development by regulating cell cycle through DNMT3B gene
The mechanism by which DNMT3B facilitates esophageal cancer (ESCA) progression is currently unknown, despite its association with adverse prognoses...
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Potential Medicinal Value of Rhein for Diabetic Kidney Disease
Diabetic kidney disease (DKD) is the primary cause of mortality among diabetic patients. With the increasing prevalence of diabetes, it has become a...
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Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy
PurposeTo construct an injectable, sustained-release fibrin gel containing rhein to solve the problem of low bioavailability of rhein, and observe...
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Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein
BackgroundRhein can significantly delay the progression of chronic nephropathy. However, its mechanism of action has not been adequately elaborated,...
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Rhein promotes the proliferation of keratinocytes by targeting oestrogen receptors for skin ulcer treatment
BackgroundThe Sheng-ji Hua-yu (SJHY) formula is a quite effective Traditional Chinese Medicines (TCM) in the treatment of delayed diabetic wounds....
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Arbeitsschutz im ehrenamtlichen Katastrophenschutz – am Beispiel des Deutschen Roten Kreuzes im Rhein-Erft-Kreis
BackgroundThe volunteer forces of the German disaster control are often active in the same fields of activity as the full-time colleagues in the...
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Impact of Covid-19 lockdowns on the anthropometric development in primary school children in the Rhein-Neckar Region, Germany
BackgroundPublished data suggests that lockdowns during the COVID-19 pandemic may have negatively affected children’s weight development. This study...
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Rhein protects 5/6 nephrectomized rat against renal injury by reducing inflammation via NF-κB signaling
Background/AimsInflammation is well known to play a pivotal role in renal injury. Rhein is a major component of the medicinal Rhubarb. The aim of...
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The REMAR (Rhein-Main-Registry) real-world study: prospective evaluation of the 21-gene breast recurrence score® assay in addition to Ki-67 for adjuvant treatment decisions in early-stage breast cancer
PurposeKi-67 is recommended by international/national guidelines for risk stratification in early breast cancer (EBC), particularly for defining...
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Design and Evaluation of Rhein-Based MRI Contrast Agents for Visualization of Tumor Necrosis Induced by Combretastatin A-4 Disodium Phosphate
PurposeVisualization of tumor necrosis can determine tumor response to therapy. Our previous study showed that the rhein-based magnetic resonance...
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Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug
Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system (CNS). Effective treatments remain limited. Therefore,...
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Synthesis and Evaluation of Ga-68-Labeled Rhein for Early Assessment of Treatment-Induced Tumor Necrosis
PurposeThis study aimed to synthesize a necrosis-avid agent using rhein as a precursor and labeled with gallium-68 (Ga-68) for positron emission...
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Research on the wound healing effect of Shengji Huayu Formula ethanol extract-derived fractions in streptozotocin-induced diabetic ulcer rats
BackgroundDiabetic ulcer is a common complication of diabetes. It is characterized by a long-term disease course and high recurrence rate. Shengji...
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Paradoxical effect of anti-inflammatory drugs on IL-6 mRNA expression in patients with PTSD during treatment
The pathophysiology of posttraumatic stress disorder (PTSD) is associated with the activation of the innate immune system, including cytokines like...
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Sanhuang **exin Decoction Ameliorates TNBC By Modulating JAK2-STAT3 and Lipid Metabolism
ObjectiveTo investigate the therapeutic effect of Sanhuang **exin Decoction (SXD) on triple-negative breast cancer (TNBC) in mice and its underlying...
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Network pharmacology and molecular docking technology-based predictive study of the active ingredients and potential targets of rhubarb for the treatment of diabetic nephropathy
Diabetic nephropathy (DN) is one of the most serious complications of diabetes and the main cause of end-stage renal failure. Rhubarb is a widely...
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Vertrauliche Spurensicherung braucht kurze Wege
BackgroundThe examination of victims of violence including the confidential securing of evidence is now part of normal working practices within...
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ARENA – Projekt Vorhofflimmern in der Rhein-Neckar-Region
Atrial fibrillation (AF) is the most common form of cardiac tachyarrhythmia. It is estimated that in the Rhein-Neckar region approximately...
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SPECT Imaging of Treatment-Related Tumor Necrosis Using Technetium-99m-Labeled Rhein
PurposeNoninvasive imaging of treatment-induced necrosis is important to distinguish early responders from patients resistant to the treatment plan,...
