Search
Search Results
-
Identifying the mechanism of action of the Kv7 channel opener, retigabine in the treatment of epilepsy
Epilepsy is characterized by recurrent epileptic seizures caused by high levels of neuronal excitability in the brain. Voltage-sensitive K+ channels...
-
A novel loss-of-function mutation of the voltage-gated potassium channel Kv10.2 involved in epilepsy and autism
BackgroundNovel developmental mutations associated with disease are a continuous challenge in medicine. Clinical consequences caused by these...
-
The Potential of KCNQ Potassium Channel Openers as Novel Antidepressants
Major depressive disorder (MDD) is a leading cause of disability worldwide and less than one-third of patients with MDD achieve stable remission of...
-
Activation of Kv7 channels normalizes hyperactivity of the VTA-NAcLat circuit and attenuates methamphetamine-induced conditioned place preference and sensitization in mice
The brain circuit projecting from the ventral tegmental area (VTA) to the nucleus accumbens lateral shell (NAcLat) has a key role in methamphetamine...
-
Pharmacokinetics of XEN496, a Novel Pediatric Formulation of Ezogabine, Under Fed and Fasted Conditions: A Phase 1 Trial
IntroductionXEN496 is a novel, granular, immediate-release formulation of ezogabine intended for pediatric use. The objective of this study was to...
-
The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin
Tutin, an established toxic natural product that causes epilepsy in rodents, is often used as a tool to develop animal model of acute epileptic...
-
Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy
Impairments in cognition are common in epilepsy and may be caused or exacerbated by antiseizure medications (ASMs). Positive effects on cognition may...
-
Transient Delivery of a KCNQ2/3-Specific Channel Activator 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus
Exposure to loud noise can cause hearing loss and tinnitus in mice and humans. In mice, one major underlying mechanism of noise-induced tinnitus is...
-
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal neurodegenerative diseases and, to date, no validated diagnostic or...
-
The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond
Epilepsy is one of the most common and disabling chronic neurological disorders. Antiseizure medications (ASMs), previously referred to as...
-
Third-Generation Antiseizure Medication in the Treatment of Benzodiazepine-Refractory Status Epilepticus in Poststroke Epilepsy: A Retrospective Observational Register-Based Study
Background and ObjectiveStatus epilepticus in poststroke epilepsy is a challenging condition because of multiple vascular comorbidities and the...
-
Re-evaluating the placebo response in recent canine dietary epilepsy trials
The placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can...
-
Fenfluramine in clinical practice: new therapy option for Dravet and Lennox–Gastaut syndromes
Fenfluramine is an antiseizure medication for the treatment of Dravet and Lennox–Gastaut syndromes. This review summarizes the literature on the...
-
Current Treatment Options for Patients with Myotonic Dystrophy Type 2
Purpose of the reviewMyotonic dystrophy types 1 and 2 are frequent forms of muscular dystrophies in adulthood. Their clinical differences need to be...
-
Blue Nail Discoloration: Literature Review and Diagnostic Algorithms
Blue nail discoloration is a distinctive clinical presentation, and diagnosis is challenging given the broad differential diagnosis. A comprehensive...
-
Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations
Due to the diverse mechanisms of action of antiseizure drugs, there has been a rise in prescriptions of these drugs for non-epileptic pathologies....
-
The efficacy and safety of ketamine in the treatment of super-refractory status epilepticus: a systematic review
BackgroundKetamine, as an anesthetic, has been considered for terminating status epilepticus (SE); however, due to the urgency and severity of the...
