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Understanding daytime functioning in insomnia: responder and correlation analyses in patients treated with daridorexant
BackgroundImproving daytime functioning is a key treatment goal for patients with insomnia disorder. In a phase 3 study, using the Insomnia Daytime...
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Clinician’s Approach to Advanced Statistical Methods: Win Ratios, Restricted Mean Survival Time, Responder Analyses, and Standardized Mean Differences
Novel statistical methods have emerged in recent medical literature, which clinicians must understand to properly appraise and integrate evidence...
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Secukinumab in Ankylosing Spondylitis Patients: A Cost-per-Responder Analysis from the Indonesian Health System Perspective
ObjectiveThere are no publications that have demonstrated economic value for ankylosing spondylitis (AS) treatments in Indonesia. Cost per responder...
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The general attributes and competence for nurses in a single responder unit: A modified Delphi study
AimThe aim of this study was to describe the general attributes and competence that nurses in the ambulance’s single responder units are considered...
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Characteristics and motivational factors for joining a lay responder system dispatch to out-of-hospital cardiac arrests
BackgroundThere has been in increase in the use of systems for organizing lay responders for suspected out-of-hospital cardiac arrests (OHCAs)...
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Is there a spinal tap responder in progressive supranuclear palsy? The first prospective study
ObjectiveProgressive supranuclear palsy (PSP) is a progressive neurodegenerative disease, and sometimes shows idiopathic normal pressure...
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Increasing power in the analysis of responder endpoints in rheumatology: a software tutorial
BackgroundComposite responder endpoints feature frequently in rheumatology due to the multifaceted nature of many of these conditions. Current...
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Freeze-all policy versus luteal phase support with low dose of human chorionic gonadotrophin for high-responder patients undergoing intracytoplasmic sperm injection on pregnancy outcomes: a retrospective cohort observational study
BackgroundThe literature has always controversies on the use of freeze-all policy in high-responder women performing intracytoplasmic sperm...
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Highly Purified Human Menopausal Gonadotropin (HP-hMG) Versus Recombinant Follicle-Stimulating Hormone (rFSH) for Controlled Ovarian Stimulation in US Predicted High-Responder Patients: A Cost-Comparison Analysis
ObjectivesInfertility imposes considerable clinical and economic burden, and the high costs of fertility care are a major barrier to payers. This...
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Effects of immediate versus delayed frozen embryo transfer in high responder patients undergoing freeze-all cycles
BackgroundFrozen embryo transfer (FET) can greatly improve the pregnancy outcomes for high responder patients. However, it is not known whether the...
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Real-world Performance of a New Strategy for Off-Label Use of Guselkumab in Moderate to Severe Psoriasis: Super-Responder Patients as the Epitome of Efficacy and Optimisation
BackgroundGuselkumab is a drug used to treat moderate to severe plaque psoriasis. However, real-life clinical data on its off-label use are limited,...
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Is the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up Study
IntroductionRecently, a study showing the non-inferiority of a single injection of sodium hyaluronate plus sorbitol (Synolis VA ® ) compared to hylan...
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Gonadotropin Stimulation Reduces the Implantation and Live Birth Rate but Not the Miscarriage Rate of Embryos Transferred When Compared to Unstimulated In Vitro Fertilization
Research suggests that gonadotropin stimulation in in vitro fertilization (IVF) treatment affects embryo quality and the endometrium that might...
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Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is...
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m.4216 T > C polymorphism in JT cluster determines a lower pregnancy rate in response to controlled ovarian stimulation treatment
PurposeTo analyze the influence of Caucasian mitochondrial haplogroups on controlled ovarian stimulation outcome (COS), embryo (E), and pregnancy...
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The multi-domain responder index: a novel analysis tool to capture a broader assessment of clinical benefit in heterogeneous complex rare diseases
In traditional clinical trial design, efficacy is typically assessed using a single primary endpoint in a randomized controlled trial to detect an...
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First responder systems can stay operational under pandemic conditions: results of a European survey during the COVID-19 pandemic
BackgroundDispatching first responders (FR) to out-of-hospital cardiac arrest in addition to the emergency medical service has shown to increase...
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The effect of Myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial
BackgroundPoor ovarian response to gonadotropin is a significant challenge in assisted reproductive technique (ART) and affect 9–24% of ART cycles....
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Clinical significance of the maximum standardized uptake value on positron emission tomography to predict treatment response and outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
PurposesThe association between the reduction rate of the maximum standardized uptake value (SUVmax) on positron emission tomography (PET) during...
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Responder analysis for neuropathic impairment and quality-of-life assessment in patients with hereditary transthyretin amyloidosis with polyneuropathy in the NEURO-TTR study
ObjectiveHereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a rare disease characterized by rapid neuropathic progression. In...
