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Prediction of postoperative respiratory depression and respiratory complications in patients on preoperative methadone
PurposeWe developed prediction models for postoperative respiratory depression and respiratory complications for 958 patients who were on methadone...
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Whole body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal
BackgroundOpioid use in the United States and abroad is an endemic part of society with yearly increases in overdose rates and deaths. In response,...
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Respiratory depression following cesarean section with single-shot spinal with 100 μg morphine
PurposeLittle evidence is available regarding bradypnea measured using continuous monitoring following cesarean section. We aimed to evaluate the...
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The use of gabapentinoids and opioids and risk of develo** opioid-induced respiratory depression among older breast cancer survivors with neuropathic pain
PurposeTo estimate the combined effect of gabapentinoid and opioid therapy compared to opioid monotherapy on the risk of develo** opioid-induced...
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Incidence of postoperative opioid-induced respiratory depression episodes in patients on room air or supplemental oxygen: a post-hoc analysis of the PRODIGY trial
BackgroundSupplemental oxygen (SO) potentiates opioid-induced respiratory depression (OIRD) in experiments on healthy volunteers. Our objective was...
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Mitochondria-wide association study observed significant interactions of mitochondrial respiratory and the inflammatory in the development of anxiety and depression
The aim of this study was to investigate the possible interaction of mitochondrial dysfunction and inflammatory cytokines in the risk of anxiety and...
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Postoperative respiratory depression in patients on sublingual buprenorphine: a retrospective cohort study for comparison between postoperative continuation and discontinuation of buprenorphine
BackgroundWe tested the hypothesis that patients who continued buprenorphine postoperatively experience postoperative respiratory depression less...
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Blood-based mitochondrial respiratory chain function in major depression
Mitochondrial dysfunction has been implicated in major depressive disorder (MDD). A measure of mitochondrial respiratory chain (RC) enzymatic...
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Prevalence of Gabapentinoids and Central Nervous System Depressant Drugs, and Their Association with Risk Factors for Respiratory Depression in Primary Care Patients
Background and objectivesWarnings have been published regarding an increased risk of severe respiratory depression in patients receiving...
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The influence of chorioamnionitis on respiratory drive and spontaneous breathing of premature infants at birth: a narrative review
Most very premature infants breathe at birth but require respiratory support in order to stimulate and support their breathing. A significant...
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Cognitive complaints in patients with untreated obstructive sleep apnea versus patients with neurological and respiratory diseases: prevalence, severity and risk factors
PurposeLittle is known about cognitive complaints (self-reported problems in cognitive functioning) in patients with Obstructive Sleep Apnea (OSA)....
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Myasthenia gravis, respiratory function, and respiratory tract disease
Myasthenia gravis (MG) is characterized by muscle weakness caused by autoantibodies that bind to the postsynaptic membrane at the neuromuscular...
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Depression and risk of infectious diseases: A mendelian randomization study
Previous observational inquiries have revealed a correlation between depression and infectious maladies. This study seeks to elucidate the causal...
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Anxiety and depression among COVID-19 survivors: a cross-sectional study
BackgroundThe novel coronavirus disease (COVID-19) outbreak has spread globally and resulted in physical suffering in addition to its negative...
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Incidence and Severity of Depression Among Recovered African Americans with COVID-19-Associated Respiratory Failure
BackgroundCoronavirus disease (COVID-19) disproportionately affects African Americans, and they tend to experience more severe course and adverse...
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Prevalence and correlates of stress, anxiety, and depression in patients with chronic diseases: a cross-sectional study
BackgroundMany chronic diseases, including diabetes, heart disease, cancer, and respiratory problems, can lead to emotional distress, anxiety, and...
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Opioid-induced respiratory depression increases hospital costs and length of stay in patients recovering on the general care floor
BackgroundOpioid-induced respiratory depression is common on the general care floor. However, the clinical and economic burden of respiratory...
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Comorbidity of depression and anxiety with obstructive sleep apnea in a sample of Egyptian patients
BackgroundOver the past 2 decades, sleep researchers have made significant advances in understanding sleep disorders including obstructive sleep...
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Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice
Opioid drugs are widely used analgesics that activate the G protein-coupled µ-opioid receptor, whose endogenous neuropeptide agonists, endorphins and...
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Pupillary unrest, opioid intensity, and the impact of environmental stimulation on respiratory depression
Opioid-induced respiratory depression (OIRD) confers significant morbidity, but its onset can be challenging to recognize. Pain or stimulation...
