Search
Search Results
-
Mechanism of cisplatin resistance in gastric cancer and associated microRNAs
Gastric cancer (GC) is a common malignant tumor with high morbidity and mortality rates that seriously affects human health worldwide. Although...
-
Mechanism of action, resistance, interaction, pharmacokinetics, pharmacodynamics, and safety of fostemsavir
The Food and Drug Administration (FDA) has licensed many antiretroviral medications to treat human immunodeficiency virus type 1 (HIV-1), however,...
-
Drug resistance in breast cancer is based on the mechanism of exocrine non-coding RNA
Breast cancer (BC) ranks first among female malignant tumors and involves hormonal changes and genetic as well as environmental risk factors. In...
-
Novel mechanism of drug resistance triggered by tumor-associated macrophages through Heat Shock Factor-1 activation
Macrophages constitute a major part of tumor microenvironment, and most of existing data demonstrate their ruling role in the development of...
-
Holistic anti-tumor resistance mechanism of YBX1 and its potential as a chemoresistance target in pancreatic ductal adenocarcinoma
The overall survival rate of pancreatic ductal adenocarcinoma (PDAC) is the worst among all cancers, which is mainly due to the fact that most...
-
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of cutaneous melanoma (CM), and...
-
Molecular mechanism of XB130 adaptor protein mediates trastuzumab resistance in gastric cancer
BackgroundRecent studies have shown that the activation of PI3K/AKT signaling pathway is an essential molecular mechanism participating in...
-
Posttranslational splicing modifications as a key mechanism in cytarabine resistance in acute myeloid leukemia
Despite the approval of several drugs for AML, cytarabine is still widely used as a therapeutic approach. However, 85% of patients show resistance...
-
Adipose-derived extracellular vesicles – a novel cross-talk mechanism in insulin resistance, non-alcoholic fatty liver disease, and polycystic ovary syndrome
Obesity is the best described risk factor for the development of non-alcoholic fatty liver disease (NAFLD)/metabolic dysfunction associated steatotic...
-
Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia
Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25 % of acute myeloid leukemia (AML) patients, drive leukemia...
-
Molecular mechanism of MLCK1 inducing 5-Fu resistance in colorectal cancer cells through activation of TNFR2/NF-κB pathway
Background and aimsChemotherapy resistance in colorectal cancer have been faced with significant challenges in recent years. Particular interest is...
-
Whole-exome sequencing explored mechanism of selpercatinib resistance in RET-rearranged lung adenocarcinoma transformation into small-cell lung cancer: a case report
Small cell transformation was one mechanism by which EGFR -mutation NSCLC acquired resistance after tyrosine kinase inhibitors (TKIs) treatment. A few...
-
Establishment of an acquired lorlatinib-resistant cell line of non-small cell lung cancer and its mediated resistance mechanism
PurposeAlthough lorlatinib, the third generation of echinoderm microtubule protein 4-anaplastic lymphoma kinase (EML4-ALK) tyrosine kinase inhibitor...
-
Butyrate driven raft disruption trots off enteric pathogen invasion: possible mechanism of colonization resistance
The gut microbiome derived short chain fatty acids perform multitude of functions to maintain gut homeostasis. Here we studied how butyrate stymie...
-
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters
BackgroundThe drug resistance of tumor stem cells is an obstacle in gastric cancer (GC) treatment and the high expression of ABC transporters is a...
-
Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1
The androgen receptor (AR) is a central driver of aggressive prostate cancer. After initial treatment with androgen receptor signaling inhibitors...
-
Mechanism of insulin resistance in obesity: a role of ATP
Obesity increases the risk of type 2 diabetes through the induction of insulin resistance. The mechanism of insulin resistance has been extensively...
-
Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition
Acquired resistance to molecular targeted therapy is a significant challenge of the precision medicine era. The ability to understand these...
-
A retrospective study on the mechanism underlying quick transfer from response to resistance in a repeated recurrent chordoma patient with molecular alterations treated with Palbociclib
PurposeThere is no approved targeted therapy for chordoma at present. Although several preclinical studies have implied the potential applicability...
-
O-GlcNAcylation of melanophilin enhances radiation resistance in glioblastoma via suppressing TRIM21 mediated ubiquitination
The molecular mechanism of glioblastoma (GBM) radiation resistance remains poorly understood. The aim of this study was to elucidate the potential...
