Search
Search Results
-
Drug repurposing for cancer therapy
Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical,...
-
Network-based drug repurposing for schizophrenia
Despite recent progress, the challenges in drug discovery for schizophrenia persist. However, computational drug repurposing has gained popularity as...
-
Protein sequence analysis in the context of drug repurposing
MotivationDrug repurposing speeds up the development of new treatments, being less costly, risky, and time consuming than de novo drug discovery....
-
Using word evolution to predict drug repurposing
BackgroundTraditional literature based discovery is based on connecting knowledge pairs extracted from separate publications via a common mid point...
-
Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer’s disease with real-world clinical validation
Drug repurposing represents an attractive alternative to the costly and time-consuming process of new drug development, particularly for serious,...
-
Drug Repurposing of Generic Drugs: Challenges and the Potential Role for Government
Drug repurposing is the process of identifying a new use for an existing drug or active substance in an indication outside the scope of the original...
-
Repurposing phone booths into COVID-19 sampling stations: medical operator experiences
This study investigated the repurposing of phone booths into COVID-19 sampling stations and assessed medical operator experiences in twelve...
-
Selection of clinically relevant drug concentrations for in vitro studies of candidates drugs for cancer repurposing: a proposal
Drug repurposing of widely prescribed patent-off and cheap drugs may provide affordable drugs for cancer treatment. Nevertheless, many preclinical...
-
Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Cancer poses a significant global health challenge, with predictions of increasing prevalence in the coming years due to limited prevention, late...
-
Integrative rare disease biomedical profile based network supporting drug repurposing or repositioning, a case study of glioblastoma
BackgroundGlioblastoma (GBM) is the most aggressive and common malignant primary brain tumor; however, treatment remains a significant challenge....
-
Does Therapeutic Repurposing in Cancer Meet the Expectations of Having Drugs at a Lower Price?
Therapeutic repurposing emerged as an alternative to the traditional drug discovery and development model (DDD) of new molecular entities (NMEs). It...
-
Computational drug repurposing based on electronic health records: a sco** review
Computational drug repurposing methods adapt Artificial intelligence (AI) algorithms for the discovery of new applications of approved or...
-
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro
BackgroundThere is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a...
-
Repurposing drugs to treat cardiovascular disease in the era of precision medicine
Drug repurposing is the use of a given therapeutic agent for indications other than that for which it was originally designed or intended. The...
-
Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million...
-
Drug repurposing: a systematic review on root causes, barriers and facilitators
BackgroundRepurposing is a drug development strategy receiving heightened attention after the Food and Drug Administration granted emergency use...
-
Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review
While majority of the current treatment approaches for cancer remain expensive and are associated with several side effects, development of new...
-
Repurposing of triamterene as a histone deacetylase inhibitor to overcome cisplatin resistance in lung cancer treatment
PurposeCisplatin is the core chemotherapeutic drug used for first-line treatment of advanced non-small cell lung cancer (NSCLC). However, drug...
-
Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice
Metformin, a primary anti-diabetic medication, has been anticipated to provide benefits for Alzheimer’s disease (AD), also known as “type 3...
