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PDGFRα reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair
The outer coverings of the skeleton, which is also known as the periosteum, are arranged in concentric layers and act as a reservoir for...
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An Investigation of Inter-Rater and Intra-Proxy Agreement in Measuring Quality of Life of Children in the Community Using the EQ-5D-Y-3L
BackgroundSelf-reporting of health-related quality of life (HRQoL) in children is not always feasible. To date, proxy perspectives (Proxy versions 1...
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Agreement between older adult patient and caregiver proxy symptom reports
BackgroundProxy report is essential for patients unable to complete patient-reported outcome (PRO) measures themselves and potentially beneficial...
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CRISPR/Cas9-based generation of a recombinant double-reporter pseudorabies virus and its characterization in vitro and in vivo
Pseudorabies, caused by pseudorabies virus (PRV) variants, has broken out among commercial PRV vaccine-immunized swine herds and resulted in major...
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Low agreement between kidney volume and kidney length z-scores
BackgroundPediatric nephrologists use kidney length and kidney volume z-scores to longitudinally assess normal nephron endowment. However, most...
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Agreement between proxy- and self-report scores on PROMIS health-related quality of life domains in pediatric burn survivors: a National Institute on Disability, Independent Living, and Rehabilitation Research Burn Model System Study
PurposeTo examine agreement between pediatric burn survivor self- and caregiver proxy-report on multiple PROMIS domains and examine factors...
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A molecular toolbox to study progesterone receptor signaling
Progesterone receptor (PR) signaling is required for mammary gland development and homeostasis. A major bottleneck in studying PR signaling is the...
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Clinical validation of engineered CRISPR/Cas12a for rapid SARS-CoV-2 detection
BackgroundThe coronavirus disease (COVID-19) caused by SARS-CoV-2 has swept through the globe at an unprecedented rate. CRISPR-based detection...
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LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells
BackgroundThe benefits of first-line, cisplatin-based chemotherapy for muscle-invasive bladder cancer are limited due to intrinsic or acquired...
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Neurotoxin-Derived Optical Probes for Biological and Medical Imaging
The superb specificity and potency of biological toxins targeting various ion channels and receptors are of major interest for the delivery of...
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A qualitative study to explore symptoms and impacts of pediatric and adolescent Crohn’s disease from patient and caregiver perspective
BackgroundCrohn’s disease (CD) is a chronic inflammatory condition of the gastrointestinal tract that affects people across the age spectrum but...
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MiR-34a-5p suppresses cutaneous squamous cell carcinoma progression by targeting SIRT6
Cutaneous squamous cell carcinoma (cSCC) is a malignant tumor originating from epidermal or appendageal keratinocytes, with a rising incidence in...
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Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of p21
Cancer stem cells (CSCs) are mainly responsible for tumorigenesis, chemoresistance, and cancer recurrence. CSCs growth and progression are regulated...
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The clinical musculoskeletal ultrasonography: Egyptian guidelines for structured musculoskeletal ultrasound scanning and reporting
BackgroundThe aim of this work is to set up the standards for performing musculoskeletal ultrasound scans and reporting as an additional procedure in...
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Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion
BackgroundPlexiform lesions, which have a dynamic appearance in structure and cellular composition, are the histological hallmark of severe pulmonary...
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Fibulin-3 sponges Tiam1 to manipulate MMP-7 activity through β-catenin signaling in oral squamous cell carcinoma
Oral squamous cell carcinoma (named OSCC) is considered the most frequent malignancy in oral cavity, which has become a rapid increasing problem for...
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MiR-150-5p contributes to unexplained recurrent spontaneous abortion by targeting VEGFA and downregulating the PI3K/AKT/mTOR signaling pathway
PurposeThe purpose of this study is to investigate the function of miR-150-5p in URSA.
MethodTwenty-six chorionic villous tissues were collected to...
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Oct4 activates IL-17A to orchestrate M2 macrophage polarization and cervical cancer metastasis
BackgroundCervical cancer is a common malignant tumor in the female. Interleukin (IL)-17A is a proinflammatory factor and exerts a vital function in...
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CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-κB signaling
BackgroundIt has been widely shared that the dysregulation of circular RNA (circRNA) may contribute to the progression of osteoarthritis (OA). OA is...
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Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL
ObjectivetRNA-derived small RNAs (tsRNAs) are novel non-coding RNAs with various functions in multiple cancers. Nevertheless, whether vitamin D...
