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De novo versus recurrent metastatic breast cancer affects the extent of brain metastases
PurposeWe aimed to identify factors associated with the extent of brain metastases in patients with breast cancer to help distinguish brain...
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Genetic Testing in Metastatic Breast Cancer in the USA: A Podcast
This podcast highlights the importance of genetic testing in patients with metastatic breast cancer, with a specific focus on germline or inherited...
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Clinical subtype, treatment response, and survival in De Novo and recurrent metastatic breast cancer
PurposeThis study evaluated whether patients with de novo metastatic breast cancer (MBC) have superior outcomes compared to those with recurrent MBC...
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RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence
Recurrence remains a significant clinical barrier to improving breast cancer patient outcomes. The RON receptor is a predictor of metastatic...
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Recurrent severe hypocalcemia following chemotherapy regimen changes in advanced breast cancer: two case reports
BackgroundAs an oncologic emergency related to abnormalities in calcium metabolism, hypercalcemia associated with paraneoplastic syndrome and bone...
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Sacituzumab Govitecan: A Review in Unresectable or Metastatic HR+/HER2− Breast Cancer
Sacituzumab govitecan (TRODELVY ® ) is a first-in-class trophoblast cell-surface antigen 2 (Trop-2)–directed antibody and topoisomerase I inhibitor...
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Metastatic Triple-Negative Breast Cancer
Purpose of ReviewTriple-negative breast cancer (TNBC) is a heterogeneous disease group with a known aggressive phenotype and poor prognosis. To date,...
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Cost of illness of HER2-positive and metastatic and recurrent HER2-positive breast cancer – a Danish register-based study from 2005 to 2016
BackgroundInformation and knowledge about cost of illness and labour productivity in patients with HER2-positive early-stage and metastatic breast...
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Tolerability and effectiveness of palbociclib in older women with metastatic breast cancer
PurposePalbociclib has become the standard of care for estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 negative (HER2-)...
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Nab-paclitaxel plus platinum versus paclitaxel plus platinum as first-line therapy in patients with metastatic or recurrent cervical cancer
PurposeThis study aimed to assess the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus platinum versus paclitaxel...
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Tumor heterogeneity and clinically invisible micrometastases in metastatic breast cancer—a call for enhanced surveillance strategies
The biology of metastatic breast cancer (MBC) is understudied, primarily due to the difficulty of procuring multiple samples from patients with...
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Pre-operative Radiation and Immunotherapy in the Treatment of Non-metastatic Breast Cancer
Purpose of ReviewTo discuss the rationale and latest strategies for combining pre-operative radiation therapy (pre-op RT) and immunotherapy (IO) in...
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Survival, treatment patterns, and costs of HER2+ metastatic breast cancer patients in Ontario between 2005 to 2020
BackgroundTo enable the integration of novel therapies, it is critical to understand current long-term outcomes in HER2-positive metastatic breast...
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A phase Ib study of camrelizumab in combination with apatinib and fuzuloparib in patients with recurrent or metastatic triple-negative breast cancer
BackgroundStrategies to improve activity of immune checkpoint inhibitors for triple-negative breast cancer (TNBC) are needed. Preclinical studies...
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Trastuzumab Deruxtecan: A Review in Unresectable or Metastatic HER2-Positive Breast Cancer
Trastuzumab deruxtecan (Enhertu ® ) is a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate approved in several...
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The Japanese Breast Cancer Society Clinical Practice Guidelines for surgical treatment of breast cancer, 2022 edition
The 2022 revision of the Japanese Breast Cancer Society (JBCS) Clinical Practice Guidelines for surgical treatment of breast cancer was updated...
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Imaging in metastatic breast cancer, CT, PET/CT, MRI, WB-DWI, CCA: review and new perspectives
BackgroundBreast cancer is the most frequent cancer in women and remains the second leading cause of death in Western countries. It represents a...
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Pertuzumab, trastuzumab, and docetaxel for Chinese patients with previously untreated HER2-positive locally recurrent or metastatic breast cancer (PUFFIN): final analysis of a phase III, randomized, double-blind, placebo-controlled study
PurposePUFFIN (NCT02896855), a Chinese bridging study in patients with previously untreated HER2-positive locally recurrent or metastatic breast...
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Efficacy and Safety of BP02 (Trastuzumab Biosimilar) in HER2-Positive Metastatic Breast Cancer: A Multicenter Phase III Study
Background and ObjectiveTrastuzumab targets human epidermal growth factor receptor 2 (HER2) receptors and is indicated for treating HER2-positive...
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Promising Therapeutic Targets for Recurrent/Metastatic Anaplastic Thyroid Cancer
Anaplastic thyroid cancer presents formidable challenges, particularly in cases of recurrence or metastasis. Timely BRAF V600E testing is imperative...
