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Crosstalk between muscle and bone
Clinical studies revealed a relationship between osteoporosis and sarcopenia. Based on this background, crosstalk between muscle and bone has emerged...
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Bone-organ axes: bidirectional crosstalk
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various...
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The mechanism of dendritic cell-T cell crosstalk in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by joint pain and swelling, synovial hyperplasia, cartilage damage, and...
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Mitochondria-Associated Organelle Crosstalk in Myocardial Ischemia/Reperfusion Injury
Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury. This damage often leads to disruption of endoplasmic...
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Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and pancreatic β-cell dysfunction, which result from the...
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Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression
Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progression. A tumor subpopulation called liver cancer...
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The SUMOylation and ubiquitination crosstalk in cancer
BackgroundThe cancer occurrence and progression are largely affected by the post-translational modifications (PTMs) of proteins. Currently, it has...
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Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation
Progesterone (P4) and estradiol (E2) have been shown to stimulate and regulate breast cancer proliferation via classical nuclear receptor signaling...
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Bone-Muscle Crosstalk: Musculoskeletal Complications of Chemotherapy
Purpose of ReviewChemotherapy drugs combat tumor cells and reduce metastasis. However, a significant side effect of some chemotherapy strategies is...
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Pharmaceutical targeting of the cannabinoid type 1 receptor impacts the crosstalk between immune cells and islets to reduce insulitis in humans
Aims/hypothesisInsulitis, a hallmark of inflammation preceding autoimmune type 1 diabetes, leads to the eventual loss of functional beta cells....
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Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain
Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor (GABA A R) mediated inhibition...
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Tumor metabolic crosstalk and immunotherapy
Tumor cells must resist the host's immune system while maintaining growth under harsh conditions of acidity and hypoxia, which indicates that tumors...
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The Role of Tumor Epithelial-Mesenchymal Transition and Macrophage Crosstalk in Cancer Progression
Purpose of ReviewThe purpose of this review is to summarize the recently published findings regarding the role of epithelial to mesenchymal...
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Targeting adipocyte–immune cell crosstalk to control breast cancer progression
Adipocytes are crucial components of breast cancer and are involved in regulating the progression, therapeutic efficacy, and prognosis of breast...
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Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury
Organ crosstalk is a complex biological communication between distal organs mediated via cellular, soluble, and neurohormonal actions, based on a...
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Neuroimmune crosstalk and its impact on cancer therapy and research
Cancer is a major health problem as it is the first or second leading cause of death worldwide. The global cancer burden is expected to rise 47%...
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Role of chemokines in the crosstalk between tumor and tumor-associated macrophages
Tumor microenvironment (TME) consists of a dynamic network of non-tumoral stromal cells, including cancer-associated fibroblasts, endothelial cells,...
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RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment
The fate of leukaemia stem cells (LSCs) is determined by both their inherent mechanisms and crosstalk with their niches. Although LSCs were confirmed...
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Targeting crosstalk of signaling pathways in cancer stem cells: a promising approach for development of novel anti-cancer therapeutics
Wnt, Hedgehog (Hh), and Notch signaling pathways are the evolutionarily conserved signaling pathways that regulate the embryonic development and also...
