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Patient characteristics and reasons for discontinuation in a cardiovascular risk management programme in The Netherlands
BackgroundSince 2010, an increasing number of patients have participated in a nurse-led integrated cardiovascular risk management programme in the...
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Comparing the reasons for contraceptive discontinuation between parenting adolescents and young women in sub-Saharan Africa: a multilevel analysis
BackgroundAdolescent sexual and reproductive health remains a major public health and development issue of global importance. Given that adolescents...
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Incidence and reasons for discontinuation of first-line therapy in patients with multiple myeloma: results from a historical cohort, Brazil 2009–2020
Multiple myeloma (MM) is an incurable hematological cancer requiring multiple lines of anti-myeloma regimens to promote disease remission and...
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Compliance to Topical Minoxidil and Reasons for Discontinuation among Patients with Androgenetic Alopecia
IntroductionThis study assessed the levels of compliance to topical minoxidil (TM) among male and female patients with androgenetic alopecia (AGA)...
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Reasons for discontinuation of methotrexate in the treatment of rheumatoid arthritis and challenges of methotrexate resumption: a single-center, retrospective study
BackgroundMethotrexate (MTX) is an anchor drug used for the treatment of rheumatoid arthritis (RA); hence, understanding the reasons for MTX...
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Generation-Dependent Retention Rates and Reasons for Discontinuation of Molecular Targeted Therapies in Patients with Rheumatoid Arthritis: From FIRST Registry
IntroductionThe study aimed to optimize medical care for elderly patients with rheumatoid arthritis (RA) by examining the 3-year continuation rate...
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General characteristics and reasons for the discontinuation of drug clinical trials in mainland China
BackgroundAlthough discontinuation is common in clinical trials, no study has been conducted to analyse the current situation and reasons for the...
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Thrombopoietin receptor agonist discontinuation rates and reasons among patients with immune thrombocytopenia: a study of administrative claims linked with medical chart review
Administrative claims provide a rich data source for retrospective studies of real-world clinical practice, yet some important data may be...
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Tumor necrosis factor inhibitor (TNFi) persistence and reasons for discontinuation in a predominantly male cohort with axial spondyloarthritis
Although tumor necrosis factor inhibitors (TNFi) have favorably altered the treatment landscape for patients with axial spondyloarthritis (axSpA),...
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Long–Term Outcome After Discontinuation of CGRP-Targeting Therapy for Migraine
Purpose of reviewCalcitonin gene-related peptide (CGRP)-targeting agents are potential candidates for disease-modifying migraine drugs. However, most...
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Exploring the Reasons Behind the Substantial Discontinuation Rate Among Patients Taking CT-P13 in a Large Tertiary Hospital in Western Switzerland: A Retrospective Cohort Study Using Routinely Collected Medical Data
BackgroundCT-P13 is an infliximab biosimilar that was granted market authorization in Switzerland in 2016. Despite the growing literature supporting...
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Predictors of contraceptive discontinuation in Rwanda: evidence from demographic and health survey 2019–2020
BackgroundDespite advancements, Rwanda continues to face challenges regarding contraceptive discontinuation. The 2019–2020 Rwanda Demographic and...
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Lithium-discontinuation-induced treatment refractoriness revisited
BackgroundLithium is effective in the long-term treatment of bipolar disorder. Concerns have been raised about non-responsiveness after...
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Postoperative use and early discontinuation of intravenous lidocaine in spine patients
PurposeOur institution employs a multimodal approach to manage postoperative pain after spine surgery. It involves continuous intravenous (IV)...
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Patient-Reported Reasons for Antihypertensive Medication Change: A Quantitative Study Using Social Media
IntroductionHypertension is the leading cause of heart disease in the world, and discontinuation or nonadherence of antihypertensive medication...
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Peritoneal dialysis discontinuation: to the root of the problem
As the global burden of chronic kidney disease continues to increase, the use of peritoneal dialysis is often advocated as the preferred initial...
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Disentangling pharmacological and expectation effects in antidepressant discontinuation among patients with fully remitted major depressive disorder: study protocol of a randomized, open-hidden discontinuation trial
BackgroundAntidepressants are established as an evidence-based, guideline-recommended treatment for Major Depressive Disorder. Prescriptions have...
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Factors associated with discontinuation in fertility treatment: a systematic sco** review
PurposeThe discontinuation of fertility treatment could decrease the chances of achieving parenthood for infertile patients and often leads to...
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Discontinuation of psychotropic medication: a synthesis of evidence across medication classes
Pharmacotherapy is an effective treatment modality across psychiatric disorders. Nevertheless, many patients discontinue their medication at some...
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Study protocol: combined N-of-1 trials to assess open-label placebo treatment for antidepressant discontinuation symptoms [FAB-study]
BackgroundAntidepressant discontinuation is associated with a broad range of adverse effects. Debilitating discontinuation symptoms can impede the...
