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Application of real-time quaking-induced conversion in Creutzfeldt–Jakob disease surveillance
BackgroundEvaluation of the application of CSF real-time quaking-induced conversion in Creutzfeldt–Jakob disease surveillance to investigate test...
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Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with average lifespan of 2–5 years after diagnosis. The...
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Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis
ObjectiveReal-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect...
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Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease
BackgroundHuman prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection...
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Characterisation of RT-QuIC negative cases from the UK National CJD Research and Surveillance programme
IntroductionIncorporation of the real-time quaking-induced conversion (RT-QuIC) assays for diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) has...
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Creutzfeldt-Jakob disease in a man surviving COVID-19: disentangling a casual or causal association by neuropathology
BackgroundLiterature reporting the onset of Creutzfeldt-Jakob disease (CJD) immediately after COVID-19 infection has strengthened a possible causal...
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Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases
Tau neurofibrillary tangles are a hallmark of Alzheimer’s disease neuropathological change. However, it remains largely unclear how distinctive...
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The risk of Creutzfeldt–Jakob disease infection in cadaveric surgical training
The usefulness of cadaver surgical training in the clinical field is already well known. In Japan, the number of universities introducing cadaver...
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Performance of a seed amplification assay for misfolded alpha-synuclein in cerebrospinal fluid and brain tissue in relation to Lewy body disease stage and pathology burden
The development of in vitro seed amplification assays (SAA) detecting misfolded alpha-synuclein (αSyn) in cerebrospinal fluid (CSF) and other tissues...
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Comparison of cerebrospinal fluid tau, ptau(181), synuclein, and 14-3-3 for the detection of Creutzfeldt–Jakob disease in clinical practice
Creutzfeldt–Jakob disease (CJD) is the leading human prion disease and is a major public health concern, with the risk of secondary iatrogenic...
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Comorbid alpha synucleinopathies in idiopathic normal pressure hydrocephalus
ObjectiveThis study aimed to determine the prevalence and clinical features of Parkinson’s disease (PD)/PD dementia (PD/PDD) or dementia with Lewy...
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APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology
Approximately half of Alzheimer’s disease (AD) brains have concomitant Lewy pathology at autopsy, suggesting that α-synuclein (α-SYN) aggregation is...
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Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia
α -Synuclein aggregation underlies pathological changes in Lewy body dementia. Recent studies highlight structural variabilities associated with α -synu...
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The cognitive phenotypes of Creutzfeldt-Jakob disease: comparison with secondary metabolic encephalopathy
BackgroundRapidly progressive cognitive impairment is a diagnostic criterion in Creutzfeldt-Jakob disease (CJD), but the diagnosis is usually reached...
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RT-QuIC detection of chronic wasting disease prion in platelet samples of white-tailed deer
BackgroundChronic wasting disease (CWD) is a prion disease of captive and free-ranging cervids. Currently, a definitive diagnosis of CWD relies on...
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Klinik und Diagnostik humaner spongiformer Enzephalopathien: ein Update
Human spongiform encephalopathies are rare transmissible neurodegenerative diseases of the brain and the nervous system that are caused by misfolding...
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Diagnostic challenge of Creutzfeldt-Jakob disease in a patient with multimorbidity: a case-report
BackgroundCreutzfeldt-Jakob disease (CJD) is a rapidly progressive and ultimately fatal neurodegenerative condition caused by prions. The clinical...
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Acceleration of sporadic Creutzfeldt–Jakob disease progression by COVID requires evidence from appropriately designed studies
The aim of this letter to the editor is to discuss the influence of SARS-CoV-2 infection on the progression of sporadic Creutzfeldt–Jakob disease...
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